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• W2520349703 abstract "Background/purpose Respiratory distress in babies with large abdominal wall defects suggests a relationship to decreased diaphragmatic movement. We evaluated pulmonary development in a fetal lamb gastroschisis model. Methods We created gastroschisis in 25 fetal lambs at 60 days gestation (group A). Controls were 14 nonoperated lambs. (Group B) were all delivered at term. Lung volume, histology, and type 1 (AT1)/type 2 (AT2) cell ratios (AT1 ratio) were determined. We subdivided group A, comparing lambs with a large defect and scoliosis [group A (S)] with the remainder [group A (NS)]. Results Twenty-five lambs survived (11 fetuses in group A and 14 fetuses in group B). Lung volume in group A (S) was less than in group A (NS) (p < 0.05). The AT1 ratio in group A was lower than in group B (p < 0.01), without any difference in radial alveolar counts (RACs) or alveolar growth, and no association between scoliosis and alveolar differentiation. Conclusion Gastroschisis in a sheep model reduces the AT1 ratio but not the RAC. Severe scoliosis affects lung volume but not the AT1 ratio, suggesting reduced diaphragmatic movement in fetuses with large abdominal defects." @default.
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• W2520349703 date "2016-12-01" @default.
• W2520349703 modified "2023-10-13" @default.
• W2520349703 title "Does a large abdominal wall defect affect lung growth?" @default.
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• W2520349703 doi "https://doi.org/10.1016/j.jpedsurg.2016.09.022" @default.
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