FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2520354325> ?p ?o ?g. }

• W2520354325 endingPage "264" @default.
• W2520354325 startingPage "256" @default.
• W2520354325 abstract "The ability of nine cooked food-derived heterocyclic aromatic amines (HCAs), such as 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2), 2-amino-6-methylpyrido[12-a:3',2'-d]imidazole (Glu-P-1), 2-amino-pyrido[12-a:3',2'-d]imidazole hydrochloride (Glu-P-2), 2-amino-9H-pyrido[2,3-b]indole (AαC), 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC), 2-amino-3-methylimidazo[4,5-f]quinolone (IQ), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine (PhIP), to activate human aryl hydrocarbon receptor (hAhR) was examined using a HepG2-A10 cell line, which has previously established from human hepatocarcinoma-derived HepG2 cells for use in hAhR-based luciferase reporter gene assays. Trp-P-1, Trp-P-2, AαC, MeAαC, IQ and MeIQx showed a definite ability to induce not only luciferase (hAhR activation) in HepG2-A10 cells but also cytochrome P450 (CYP)1A1/1A2 mRNAs in HepG2 cells, while such the ability of Glu-P-1, Glu-P-2, and PhIP was very low. In addition, all the HCAs examined, especially MeAαC and MeIQx, had a definite capacity for inhibiting the activity of ethoxyresorfin O-deethylase (CYP1As, especially CYP1A1). The present findings demonstrate that all the HCAs examined have the ability to activate hAhR and its target genes, and further confirm that these HCAs become good substrates for human CYP1A subfamily enzyme(s)." @default.
• W2520354325 created "2016-09-23" @default.
• W2520354325 creator A5029765609 @default.
• W2520354325 creator A5039121243 @default.
• W2520354325 creator A5044139714 @default.
• W2520354325 creator A5071378456 @default.
• W2520354325 creator A5083755737 @default.
• W2520354325 creator A5088978251 @default.
• W2520354325 date "2016-11-01" @default.
• W2520354325 modified "2023-10-16" @default.
• W2520354325 title "Aryl hydrocarbon receptor activation and CYP1A induction by cooked food-derived carcinogenic heterocyclic amines in human HepG2 cell lines" @default.
• W2520354325 cites W1964540935 @default.
• W2520354325 cites W1969870510 @default.
• W2520354325 cites W1982461022 @default.
• W2520354325 cites W1985222443 @default.
• W2520354325 cites W1986170848 @default.
• W2520354325 cites W1998850038 @default.
• W2520354325 cites W2005338000 @default.
• W2520354325 cites W2006668832 @default.
• W2520354325 cites W2009002829 @default.
• W2520354325 cites W2009266960 @default.
• W2520354325 cites W2033127393 @default.
• W2520354325 cites W2040185588 @default.
• W2520354325 cites W2047023695 @default.
• W2520354325 cites W2050737668 @default.
• W2520354325 cites W2062318487 @default.
• W2520354325 cites W2068986290 @default.
• W2520354325 cites W2076578237 @default.
• W2520354325 cites W2078191448 @default.
• W2520354325 cites W2084327756 @default.
• W2520354325 cites W2085426763 @default.
• W2520354325 cites W2088561799 @default.
• W2520354325 cites W2118382882 @default.
• W2520354325 cites W2128525067 @default.
• W2520354325 cites W2232834628 @default.
• W2520354325 doi "https://doi.org/10.1016/j.fct.2016.09.021" @default.
• W2520354325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27644595" @default.
• W2520354325 hasPublicationYear "2016" @default.
• W2520354325 type Work @default.
• W2520354325 sameAs 2520354325 @default.
• W2520354325 citedByCount "10" @default.
• W2520354325 countsByYear W25203543252018 @default.
• W2520354325 countsByYear W25203543252019 @default.
• W2520354325 countsByYear W25203543252020 @default.
• W2520354325 countsByYear W25203543252021 @default.
• W2520354325 countsByYear W25203543252022 @default.
• W2520354325 countsByYear W25203543252023 @default.
• W2520354325 crossrefType "journal-article" @default.
• W2520354325 hasAuthorship W2520354325A5029765609 @default.
• W2520354325 hasAuthorship W2520354325A5039121243 @default.
• W2520354325 hasAuthorship W2520354325A5044139714 @default.
• W2520354325 hasAuthorship W2520354325A5071378456 @default.
• W2520354325 hasAuthorship W2520354325A5083755737 @default.
• W2520354325 hasAuthorship W2520354325A5088978251 @default.
• W2520354325 hasConcept C104317684 @default.
• W2520354325 hasConcept C114246631 @default.
• W2520354325 hasConcept C155647269 @default.
• W2520354325 hasConcept C178790620 @default.
• W2520354325 hasConcept C185592680 @default.
• W2520354325 hasConcept C192527728 @default.
• W2520354325 hasConcept C2778818824 @default.
• W2520354325 hasConcept C2779485729 @default.
• W2520354325 hasConcept C2780362310 @default.
• W2520354325 hasConcept C2780874372 @default.
• W2520354325 hasConcept C33594762 @default.
• W2520354325 hasConcept C515207424 @default.
• W2520354325 hasConcept C55493867 @default.
• W2520354325 hasConcept C71240020 @default.
• W2520354325 hasConcept C86339819 @default.
• W2520354325 hasConceptScore W2520354325C104317684 @default.
• W2520354325 hasConceptScore W2520354325C114246631 @default.
• W2520354325 hasConceptScore W2520354325C155647269 @default.
• W2520354325 hasConceptScore W2520354325C178790620 @default.
• W2520354325 hasConceptScore W2520354325C185592680 @default.
• W2520354325 hasConceptScore W2520354325C192527728 @default.
• W2520354325 hasConceptScore W2520354325C2778818824 @default.
• W2520354325 hasConceptScore W2520354325C2779485729 @default.
• W2520354325 hasConceptScore W2520354325C2780362310 @default.
• W2520354325 hasConceptScore W2520354325C2780874372 @default.
• W2520354325 hasConceptScore W2520354325C33594762 @default.
• W2520354325 hasConceptScore W2520354325C515207424 @default.
• W2520354325 hasConceptScore W2520354325C55493867 @default.
• W2520354325 hasConceptScore W2520354325C71240020 @default.
• W2520354325 hasConceptScore W2520354325C86339819 @default.
• W2520354325 hasFunder F4320321945 @default.
• W2520354325 hasFunder F4320334764 @default.
• W2520354325 hasLocation W25203543251 @default.
• W2520354325 hasLocation W25203543252 @default.
• W2520354325 hasOpenAccess W2520354325 @default.
• W2520354325 hasPrimaryLocation W25203543251 @default.
• W2520354325 hasRelatedWork W1980496573 @default.
• W2520354325 hasRelatedWork W1988208293 @default.
• W2520354325 hasRelatedWork W1995062273 @default.
• W2520354325 hasRelatedWork W2018646164 @default.
• W2520354325 hasRelatedWork W2032485128 @default.
• W2520354325 hasRelatedWork W2053128918 @default.
• W2520354325 hasRelatedWork W2093171487 @default.
• W2520354325 hasRelatedWork W2143127166 @default.

• next