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- W2520356656 abstract "bytheMAT locus. We also have genetically mappedtheSTEIIgenetochromosome XII, 40centimorgans fromura4. Haploid cells oftheyeast Saccharomyces cerevisiae exist asoneofthetwocell types, aora.Expression ofcell (or mating) typeiscontrolled bytheallele MATaorMATa, present atthemating type(MAT)locus (4,22). Thus,with theexception oftheMAT locus, allhaploids contain the genetic information forbothcell types, butonlyMATacells express a-specific genes, whereas a-specific genesareexpressed onlyinMATacells. Thisselective activation ofaanda-specific genesbytheMAT locusoccursonthe transcriptional level (2,27,30). InMATacells, all a-specific genes arepositively regulated byoneoftheMATa-encoded genes, MATal.Theother MATagene, MATa2,negatively controls a-specific genes(32, 36). Thea-specific genesare expressed constitutively inMATacells. Animportant consequence oftheelaboration ofcell type inyeast haploids istheability ofcells ofonemating typeto matewithcells oftheopposite mating type, resulting inyet athird cell type, thea/adiploid. Thesediploids donot express either ofthehaploid-specific cell typesandare mating incompetent. Thisnegative regulation ofa-and a-specific genes isbelieved tobemediated bythecombined interaction oftheMATa2andMATalgeneproducts (7,10," @default.
- W2520356656 created "2016-09-23" @default.
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- W2520356656 date "1985-01-01" @default.
- W2520356656 modified "2023-09-26" @default.
- W2520356656 title "Molecular Cloning andCharacterization oftheSTE7andSTElI GenesofSaccharomyces cerevisiae" @default.
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