Matches in SemOpenAlex for { <https://semopenalex.org/work/W2520432895> ?p ?o ?g. }
- W2520432895 endingPage "26" @default.
- W2520432895 startingPage "17" @default.
- W2520432895 abstract "Natural food sources constitute a promising source of new compounds with neuroprotective properties, once they have the ability to reach the brain. Our aim was to evaluate the brain accessibility of quercetin, epigallocatechin gallate (EGCG) and cyanidin-3-glucoside (C3G) in relation to their neuroprotective capability. Primary cortical neuron cultures were exposed to oxidative insult in the absence and presence of the selected compounds, and neuroprotection was assessed through evaluation of apoptotic-like and necrotic-like cell death. The brain accessibility of selected compounds was assessed using an optimised human blood-brain barrier model. The blood-brain barrier model was crossed rapidly by EGCG and more slowly by C3G, but not by quercetin. EGCG protected against oxidation-induced neuronal necrotic-like cell death by ~40%, and apoptosis by ~30%. Both quercetin and C3G were less effective, since only the lowest quercetin concentration was protective, and C3G only prevented necrosis by ~37%. Quercetin, EGCG and C3G effectively inhibited α-synuclein fibrillation over the relevant timescale applied here. Overall, EGCG seems to be the most promising neuroprotective compound. Thus, inclusion of this polyphenol in the diet might provide an affordable means to reduce the impact of neurodegenerative diseases." @default.
- W2520432895 created "2016-09-23" @default.
- W2520432895 creator A5011044505 @default.
- W2520432895 creator A5011472768 @default.
- W2520432895 creator A5015341932 @default.
- W2520432895 creator A5018527113 @default.
- W2520432895 creator A5032331356 @default.
- W2520432895 creator A5035574986 @default.
- W2520432895 creator A5041603334 @default.
- W2520432895 creator A5088219344 @default.
- W2520432895 creator A5091615384 @default.
- W2520432895 date "2016-11-01" @default.
- W2520432895 modified "2023-10-02" @default.
- W2520432895 title "Potential for brain accessibility and analysis of stability of selected flavonoids in relation to neuroprotection in vitro" @default.
- W2520432895 cites W1159463284 @default.
- W2520432895 cites W1589993557 @default.
- W2520432895 cites W1824652155 @default.
- W2520432895 cites W1966615954 @default.
- W2520432895 cites W1968805857 @default.
- W2520432895 cites W1973485004 @default.
- W2520432895 cites W1973500800 @default.
- W2520432895 cites W1981145469 @default.
- W2520432895 cites W1986448801 @default.
- W2520432895 cites W1989058164 @default.
- W2520432895 cites W1990437598 @default.
- W2520432895 cites W1992924420 @default.
- W2520432895 cites W2000608533 @default.
- W2520432895 cites W2001099546 @default.
- W2520432895 cites W2007504603 @default.
- W2520432895 cites W2014712282 @default.
- W2520432895 cites W2024679196 @default.
- W2520432895 cites W2024713555 @default.
- W2520432895 cites W2027270316 @default.
- W2520432895 cites W2039842343 @default.
- W2520432895 cites W2044708797 @default.
- W2520432895 cites W2048940684 @default.
- W2520432895 cites W2051027493 @default.
- W2520432895 cites W2057541416 @default.
- W2520432895 cites W2062934118 @default.
- W2520432895 cites W2070207411 @default.
- W2520432895 cites W2077242443 @default.
- W2520432895 cites W2077274456 @default.
- W2520432895 cites W2079177429 @default.
- W2520432895 cites W2079362707 @default.
- W2520432895 cites W2083034526 @default.
- W2520432895 cites W2091915417 @default.
- W2520432895 cites W2095447381 @default.
- W2520432895 cites W2098339185 @default.
- W2520432895 cites W2103629466 @default.
- W2520432895 cites W2111797455 @default.
- W2520432895 cites W2111816207 @default.
- W2520432895 cites W2119108696 @default.
- W2520432895 cites W2139369570 @default.
- W2520432895 cites W2144535585 @default.
- W2520432895 cites W2148688897 @default.
- W2520432895 cites W2149081087 @default.
- W2520432895 cites W2158265368 @default.
- W2520432895 cites W2158977717 @default.
- W2520432895 cites W2160203602 @default.
- W2520432895 cites W2160239222 @default.
- W2520432895 cites W755237947 @default.
- W2520432895 doi "https://doi.org/10.1016/j.brainres.2016.09.020" @default.
- W2520432895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27639810" @default.
- W2520432895 hasPublicationYear "2016" @default.
- W2520432895 type Work @default.
- W2520432895 sameAs 2520432895 @default.
- W2520432895 citedByCount "55" @default.
- W2520432895 countsByYear W25204328952017 @default.
- W2520432895 countsByYear W25204328952018 @default.
- W2520432895 countsByYear W25204328952019 @default.
- W2520432895 countsByYear W25204328952020 @default.
- W2520432895 countsByYear W25204328952021 @default.
- W2520432895 countsByYear W25204328952022 @default.
- W2520432895 countsByYear W25204328952023 @default.
- W2520432895 crossrefType "journal-article" @default.
- W2520432895 hasAuthorship W2520432895A5011044505 @default.
- W2520432895 hasAuthorship W2520432895A5011472768 @default.
- W2520432895 hasAuthorship W2520432895A5015341932 @default.
- W2520432895 hasAuthorship W2520432895A5018527113 @default.
- W2520432895 hasAuthorship W2520432895A5032331356 @default.
- W2520432895 hasAuthorship W2520432895A5035574986 @default.
- W2520432895 hasAuthorship W2520432895A5041603334 @default.
- W2520432895 hasAuthorship W2520432895A5088219344 @default.
- W2520432895 hasAuthorship W2520432895A5091615384 @default.
- W2520432895 hasConcept C169760540 @default.
- W2520432895 hasConcept C185592680 @default.
- W2520432895 hasConcept C202751555 @default.
- W2520432895 hasConcept C25498285 @default.
- W2520432895 hasConcept C55493867 @default.
- W2520432895 hasConcept C71924100 @default.
- W2520432895 hasConcept C86803240 @default.
- W2520432895 hasConcept C98274493 @default.
- W2520432895 hasConceptScore W2520432895C169760540 @default.
- W2520432895 hasConceptScore W2520432895C185592680 @default.
- W2520432895 hasConceptScore W2520432895C202751555 @default.
- W2520432895 hasConceptScore W2520432895C25498285 @default.
- W2520432895 hasConceptScore W2520432895C55493867 @default.
- W2520432895 hasConceptScore W2520432895C71924100 @default.