Matches in SemOpenAlex for { <https://semopenalex.org/work/W2520441826> ?p ?o ?g. }
- W2520441826 abstract "Aβ peptides play a central role in the etiology of Alzheimer disease (AD) by exerting cellular toxicity correlated with aggregate formation. Experimental evidences showed an intraneuronal accumulation of Aβ peptides and toxic effects on mitochondrial functions. Nevertheless, the relevance of intracellular Aβ peptides in the pathophysiology of AD remained controversial. Here, we found that the two major species of Aβ peptides, in particular Aβ42, exhibited a strong negative effect on the preprotein import reactions essential for mitochondrial protein biogenesis. However, Aβ peptides only weakly interact with mitochondria and did not affect the inner membrane potential or the structure of the preprotein translocase complexes. Aβ peptides significantly decreased the import competence of mitochondrial precursor proteins through a specific co-aggregation mechanism. Co-aggregation and import inhibition were significantly stronger in case of the longer peptide Aβ42, correlating with its importance in AD pathology. Our results demonstrate that a direct interference of aggregation-prone Aβ peptides with mitochondrial protein biogenesis represents a crucial aspect of the pathobiochemical mechanisms contributing to cellular damage in AD." @default.
- W2520441826 created "2016-09-23" @default.
- W2520441826 creator A5022895159 @default.
- W2520441826 creator A5025818171 @default.
- W2520441826 creator A5073309256 @default.
- W2520441826 creator A5091401780 @default.
- W2520441826 date "2016-04-27" @default.
- W2520441826 modified "2023-09-23" @default.
- W2520441826 title "Amyloid β-peptides interfere with mitochondrial preprotein import competence by a co-aggregation process" @default.
- W2520441826 cites W1523656947 @default.
- W2520441826 cites W1528787410 @default.
- W2520441826 cites W1616122655 @default.
- W2520441826 cites W1677883125 @default.
- W2520441826 cites W1773701686 @default.
- W2520441826 cites W1933771638 @default.
- W2520441826 cites W1968364090 @default.
- W2520441826 cites W1973063270 @default.
- W2520441826 cites W1973929423 @default.
- W2520441826 cites W1979252213 @default.
- W2520441826 cites W1980825524 @default.
- W2520441826 cites W1983728938 @default.
- W2520441826 cites W1988213576 @default.
- W2520441826 cites W2001318407 @default.
- W2520441826 cites W2002364392 @default.
- W2520441826 cites W2010179451 @default.
- W2520441826 cites W2016436495 @default.
- W2520441826 cites W2024559246 @default.
- W2520441826 cites W2026268968 @default.
- W2520441826 cites W2030821334 @default.
- W2520441826 cites W2033736939 @default.
- W2520441826 cites W2035594496 @default.
- W2520441826 cites W2038680277 @default.
- W2520441826 cites W2041993377 @default.
- W2520441826 cites W2043741577 @default.
- W2520441826 cites W2048125278 @default.
- W2520441826 cites W2063699848 @default.
- W2520441826 cites W2066253841 @default.
- W2520441826 cites W2068119233 @default.
- W2520441826 cites W2073813663 @default.
- W2520441826 cites W2074668191 @default.
- W2520441826 cites W2076241970 @default.
- W2520441826 cites W2078992020 @default.
- W2520441826 cites W2079250951 @default.
- W2520441826 cites W2084094879 @default.
- W2520441826 cites W2094853890 @default.
- W2520441826 cites W2096410114 @default.
- W2520441826 cites W2101699102 @default.
- W2520441826 cites W2103440561 @default.
- W2520441826 cites W2112068811 @default.
- W2520441826 cites W2121085169 @default.
- W2520441826 cites W2126607520 @default.
- W2520441826 cites W2131143886 @default.
- W2520441826 cites W2131630367 @default.
- W2520441826 cites W2132988134 @default.
- W2520441826 cites W2133631618 @default.
- W2520441826 cites W2134802476 @default.
- W2520441826 cites W2169686783 @default.
- W2520441826 cites W2170398463 @default.
- W2520441826 cites W2240047080 @default.
- W2520441826 cites W2243723775 @default.
- W2520441826 cites W2418797359 @default.
- W2520441826 doi "https://doi.org/10.1101/050617" @default.
- W2520441826 hasPublicationYear "2016" @default.
- W2520441826 type Work @default.
- W2520441826 sameAs 2520441826 @default.
- W2520441826 citedByCount "0" @default.
- W2520441826 crossrefType "posted-content" @default.
- W2520441826 hasAuthorship W2520441826A5022895159 @default.
- W2520441826 hasAuthorship W2520441826A5025818171 @default.
- W2520441826 hasAuthorship W2520441826A5073309256 @default.
- W2520441826 hasAuthorship W2520441826A5091401780 @default.
- W2520441826 hasBestOaLocation W25204418261 @default.
- W2520441826 hasConcept C104317684 @default.
- W2520441826 hasConcept C113035283 @default.
- W2520441826 hasConcept C131934819 @default.
- W2520441826 hasConcept C138626823 @default.
- W2520441826 hasConcept C185592680 @default.
- W2520441826 hasConcept C2777229759 @default.
- W2520441826 hasConcept C2779281246 @default.
- W2520441826 hasConcept C28859421 @default.
- W2520441826 hasConcept C55493867 @default.
- W2520441826 hasConcept C75385678 @default.
- W2520441826 hasConcept C79879829 @default.
- W2520441826 hasConcept C86803240 @default.
- W2520441826 hasConcept C95444343 @default.
- W2520441826 hasConceptScore W2520441826C104317684 @default.
- W2520441826 hasConceptScore W2520441826C113035283 @default.
- W2520441826 hasConceptScore W2520441826C131934819 @default.
- W2520441826 hasConceptScore W2520441826C138626823 @default.
- W2520441826 hasConceptScore W2520441826C185592680 @default.
- W2520441826 hasConceptScore W2520441826C2777229759 @default.
- W2520441826 hasConceptScore W2520441826C2779281246 @default.
- W2520441826 hasConceptScore W2520441826C28859421 @default.
- W2520441826 hasConceptScore W2520441826C55493867 @default.
- W2520441826 hasConceptScore W2520441826C75385678 @default.
- W2520441826 hasConceptScore W2520441826C79879829 @default.
- W2520441826 hasConceptScore W2520441826C86803240 @default.
- W2520441826 hasConceptScore W2520441826C95444343 @default.
- W2520441826 hasLocation W25204418261 @default.
- W2520441826 hasLocation W25204418262 @default.