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• W2520465303 startingPage "1542" @default.
• W2520465303 abstract "Resveratrol, a dietary polyphenol, is under consideration as chemopreventive and chemotherapeutic agent for several diseases, including cancer. However, its mechanisms of action and its effects on non-tumor cells, fundamental to understand its real efficacy as chemopreventive agent, remain largely unknown. Proline-rich tyrosine kinase 2 (PYK2), a non-receptor tyrosine kinase acting as signaling mediator of different stimuli, behaves as tumor-suppressor in prostate. Since, PYK2 and RSV share several fields of interaction, including oxidative stress, we have investigated their functional relationship in human non-transformed prostate EPN cells and in their tumor-prone counterpart EPN-PKM, expressing a PYK2 dead-kinase mutant. We show that RSV has a strong biological activity in both cell lines, decreasing ROS production, inducing morphological changes and reversible growth arrest, and activating autophagy but not apoptosis. Interestingly, the PYK2 mutant increases basal ROS and autophagy levels, and modulates the intensity of RSV effects. In particular, the anti-oxidant effect of RSV is more potent in EPN than in EPN-PKM, whereas its anti-proliferative and pro-autophagic effects are more significant in EPN-PKM. Consistently, PYK2 depletion by RNAi replicates the effects of the PKM mutant. Taken together, our results reveal that PYK2 and RSV act on common cellular pathways and suggest that RSV effects on prostate cells may depend on mutational-state or expression levels of PYK2 that emerges as a possible mediator of RSV mechanisms of action. Moreover, the observation that resveratrol effects are reversible and not associated to apoptosis in tumor-prone EPN-PKM cells suggests caution for its use in humans." @default.
• W2520465303 created "2016-09-23" @default.
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• W2520465303 date "2016-09-13" @default.
• W2520465303 modified "2023-10-16" @default.
• W2520465303 title "Convergent Effects of Resveratrol and PYK2 on Prostate Cells" @default.
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• W2520465303 cites W1951997517 @default.
• W2520465303 cites W1953581730 @default.
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• W2520465303 cites W1963978740 @default.
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• W2520465303 cites W1988043615 @default.
• W2520465303 cites W1989357594 @default.
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• W2520465303 cites W2021573908 @default.
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• W2520465303 cites W2073717392 @default.
• W2520465303 cites W2077462076 @default.
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• W2520465303 cites W2079051863 @default.
• W2520465303 cites W2079125118 @default.
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• W2520465303 cites W2121412173 @default.
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• W2520465303 doi "https://doi.org/10.3390/ijms17091542" @default.
• W2520465303 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5037816" @default.
• W2520465303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27649143" @default.
• W2520465303 hasPublicationYear "2016" @default.
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