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- W2520512178 abstract "Objective Input deprived (sub)networks of cortical neurons may become hyper excitable, possibly causing certain types of epilepsy. Electrical stimulation and application of the mildly excitatory neurotransmitter ghrelin have been shown to reduce this hyper excitability, suggesting that it is a generic feature of mild excitation. Therefore, we hypothesize that another mildly excitatory agent, orexin-A (OXA), should also reduce excitability. Methods We used cultures of cortical neurons on multi electrode arrays to measure network activity. If left in isolation, activity patterns typically contain bursts that reflect network hyper excitability. The relative contribution of bursts to the total amount of spikes was used as a measure for excitability and assessed by the burstiness index (BI = 1 → burst dominated; BI = 0 → no bursts). Results Acute application of 1 μM OXA significantly increased the level of activity from 1500 ± 650(SEM) to 3200 ± 1300 spikes/min. Burstiness index dropped from 0.75 ± 0.09 to 0.58 ± 0.09 indicating more dispersed firing. Conclusions Like electrical stimulation or ghrelin, OXA mildly activates cultured networks of cortical neurons and reduces burstiness. Key message Besides cellular hyper excitability, networks may also become hyper excitable in case of insufficient ongoing activation. This may be treated by mild activation, rather than the commonly used anti-epileptic drugs that aim to reduce activity." @default.
- W2520512178 created "2016-09-23" @default.
- W2520512178 creator A5003929961 @default.
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- W2520512178 date "2016-03-01" @default.
- W2520512178 modified "2023-09-26" @default.
- W2520512178 title "ID 32 – Mild network activation by orexin - A avoids hyper excitability in input deprived cortical networks" @default.
- W2520512178 doi "https://doi.org/10.1016/j.clinph.2015.11.167" @default.
- W2520512178 hasPublicationYear "2016" @default.
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