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• W2520590970 abstract "The bile acid receptor TGR5 (also known as GPBAR1) is a promising target for the development of pharmacological interventions in metabolic diseases, including type 2 diabetes, obesity, and non-alcoholic steatohepatitis. TGR5 is expressed in many metabolically active tissues, but complex enterohepatic bile acid cycling limits the exposure of some of these tissues to the receptor ligand. Profound interspecies differences in the biology of bile acids and their receptors in different cells and tissues exist. Data from preclinical studies show promising effects of targeting TGR5 on outcomes such as weight loss, glucose metabolism, energy expenditure, and suppression of inflammation. However, clinical studies are scarce. We give a summary of key concepts in bile acid metabolism; outline different downstream effects of TGR5 activation; and review available data on TGR5 activation, with a focus on the translation of preclinical studies into clinically applicable findings. Studies in rodents suggest an important role for Tgr5 in Glp-1 secretion, insulin sensitivity, and energy expenditure. However, evidence of effects on these processes from human studies is less convincing. Ultimately, safe and selective human TGR5 agonists are needed to test the therapeutic potential of TGR5. The bile acid receptor TGR5 (also known as GPBAR1) is a promising target for the development of pharmacological interventions in metabolic diseases, including type 2 diabetes, obesity, and non-alcoholic steatohepatitis. TGR5 is expressed in many metabolically active tissues, but complex enterohepatic bile acid cycling limits the exposure of some of these tissues to the receptor ligand. Profound interspecies differences in the biology of bile acids and their receptors in different cells and tissues exist. Data from preclinical studies show promising effects of targeting TGR5 on outcomes such as weight loss, glucose metabolism, energy expenditure, and suppression of inflammation. However, clinical studies are scarce. We give a summary of key concepts in bile acid metabolism; outline different downstream effects of TGR5 activation; and review available data on TGR5 activation, with a focus on the translation of preclinical studies into clinically applicable findings. Studies in rodents suggest an important role for Tgr5 in Glp-1 secretion, insulin sensitivity, and energy expenditure. However, evidence of effects on these processes from human studies is less convincing. Ultimately, safe and selective human TGR5 agonists are needed to test the therapeutic potential of TGR5." @default.
• W2520590970 created "2016-09-23" @default.
• W2520590970 creator A5010029482 @default.
• W2520590970 creator A5020534914 @default.
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• W2520590970 creator A5079352451 @default.
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• W2520590970 creator A5088231691 @default.
• W2520590970 date "2017-03-01" @default.
• W2520590970 modified "2023-09-30" @default.
• W2520590970 title "Clinical relevance of the bile acid receptor TGR5 in metabolism" @default.
• W2520590970 cites W1523071223 @default.
• W2520590970 cites W1537062032 @default.
• W2520590970 cites W1541434960 @default.
• W2520590970 cites W1564206240 @default.
• W2520590970 cites W1895112498 @default.
• W2520590970 cites W1901029932 @default.
• W2520590970 cites W1911520061 @default.
• W2520590970 cites W1915022071 @default.
• W2520590970 cites W1965707743 @default.
• W2520590970 cites W1965796890 @default.
• W2520590970 cites W1967056255 @default.
• W2520590970 cites W1967283548 @default.
• W2520590970 cites W1970465623 @default.
• W2520590970 cites W1971627211 @default.
• W2520590970 cites W1973032731 @default.
• W2520590970 cites W1974800489 @default.
• W2520590970 cites W1976008117 @default.
• W2520590970 cites W1980021514 @default.
• W2520590970 cites W1982778563 @default.
• W2520590970 cites W1983228333 @default.
• W2520590970 cites W1985209274 @default.
• W2520590970 cites W1985539406 @default.
• W2520590970 cites W1987843898 @default.
• W2520590970 cites W1989023250 @default.
• W2520590970 cites W1989295954 @default.
• W2520590970 cites W1993970282 @default.
• W2520590970 cites W1994107529 @default.
• W2520590970 cites W1995185452 @default.
• W2520590970 cites W2000818514 @default.
• W2520590970 cites W2003221677 @default.
• W2520590970 cites W2005230264 @default.
• W2520590970 cites W2005355336 @default.
• W2520590970 cites W2007563846 @default.
• W2520590970 cites W2013247746 @default.
• W2520590970 cites W2014783968 @default.
• W2520590970 cites W2016633536 @default.
• W2520590970 cites W2016732441 @default.
• W2520590970 cites W2017362076 @default.
• W2520590970 cites W2027954881 @default.
• W2520590970 cites W2030721649 @default.
• W2520590970 cites W2034203849 @default.
• W2520590970 cites W2035391709 @default.
• W2520590970 cites W2044429737 @default.
• W2520590970 cites W2047037780 @default.
• W2520590970 cites W2049891083 @default.
• W2520590970 cites W2052638070 @default.
• W2520590970 cites W2053833972 @default.
• W2520590970 cites W2055598669 @default.
• W2520590970 cites W2056709950 @default.
• W2520590970 cites W2061278204 @default.
• W2520590970 cites W2065051999 @default.
• W2520590970 cites W2070129154 @default.
• W2520590970 cites W2070737616 @default.
• W2520590970 cites W2079737026 @default.
• W2520590970 cites W2081028309 @default.
• W2520590970 cites W2081271380 @default.
• W2520590970 cites W2082299306 @default.
• W2520590970 cites W2083260532 @default.
• W2520590970 cites W2084877538 @default.
• W2520590970 cites W2085673449 @default.
• W2520590970 cites W2088762974 @default.
• W2520590970 cites W2095536002 @default.
• W2520590970 cites W2096418655 @default.
• W2520590970 cites W2103797163 @default.
• W2520590970 cites W2106036385 @default.
• W2520590970 cites W2106225626 @default.
• W2520590970 cites W2107953386 @default.
• W2520590970 cites W2112257826 @default.
• W2520590970 cites W2113961306 @default.
• W2520590970 cites W2117845787 @default.
• W2520590970 cites W2119976901 @default.
• W2520590970 cites W2126377012 @default.
• W2520590970 cites W2127182112 @default.
• W2520590970 cites W2128045275 @default.
• W2520590970 cites W2132275840 @default.
• W2520590970 cites W2134153423 @default.
• W2520590970 cites W2143383690 @default.
• W2520590970 cites W2146764867 @default.
• W2520590970 cites W2150807020 @default.
• W2520590970 cites W2153813367 @default.
• W2520590970 cites W2158609797 @default.
• W2520590970 cites W2160835284 @default.
• W2520590970 cites W2166561625 @default.
• W2520590970 cites W2167430231 @default.
• W2520590970 cites W2169078659 @default.
• W2520590970 cites W2170061564 @default.

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