Matches in SemOpenAlex for { <https://semopenalex.org/work/W2520736812> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2520736812 abstract "PGE1 is one of prostaglandins which inhibit platelet functions and have vasodilating activity as well as PGI2. Newly developed PGE1 analogue (ONO-1206) was supplied for the clinical evaluations by Ono Pharmaceutical Company. This research was performed to analyze the effect of orally administered ONO-1206 on platelet functions and to evaluate the usefulness on the thromboembolic disorders.Comparing with PGI2, this analogue demonstrated the similar inhibitory activity on the platelet aggregation in the in vitro study. Oral administration of ONO-1206 on the patients with thromboembolic disorders showed the dose-dependent inhibition on platelet aggregation and adhesiveness. This activity continued for 180min. (max. at 120min.). Daily oral administration (20μg or 30μg t. i. d.) was continued for two weeks and its effect on blood pressure, heart rate, platelet aggregation, platelet adhesiveness, and platelet c-AMP level were evaluated. Both of administration doses caused remarkable depression of platelet aggregation and increase of platelet c-AMP level and mild suppression on the platelet adhesiveness. Blood pressure was decreased in almost all cases but heart rate remained unchanged. Clinical improvement of symptoms were observed in the patients with deep vein thrombosis or angina pectoris.These results suggest the effectiveness and usefulness of this oraly administered PGE1 analogue against the prevention and treatment of thromboembolic disorders." @default.
- W2520736812 created "2016-09-23" @default.
- W2520736812 creator A5007564749 @default.
- W2520736812 creator A5030608762 @default.
- W2520736812 creator A5032816263 @default.
- W2520736812 creator A5040269086 @default.
- W2520736812 creator A5042397704 @default.
- W2520736812 creator A5047706524 @default.
- W2520736812 creator A5069491876 @default.
- W2520736812 creator A5071002138 @default.
- W2520736812 creator A5074292766 @default.
- W2520736812 creator A5084207416 @default.
- W2520736812 date "1982-01-01" @default.
- W2520736812 modified "2023-09-24" @default.
- W2520736812 cites W1998826779 @default.
- W2520736812 cites W2019579182 @default.
- W2520736812 cites W2021403302 @default.
- W2520736812 cites W2029134608 @default.
- W2520736812 cites W2030768867 @default.
- W2520736812 cites W2062185761 @default.
- W2520736812 cites W2084022228 @default.
- W2520736812 doi "https://doi.org/10.2491/jjsth1970.13.142" @default.
- W2520736812 hasPublicationYear "1982" @default.
- W2520736812 type Work @default.
- W2520736812 sameAs 2520736812 @default.
- W2520736812 citedByCount "0" @default.
- W2520736812 crossrefType "journal-article" @default.
- W2520736812 hasAuthorship W2520736812A5007564749 @default.
- W2520736812 hasAuthorship W2520736812A5030608762 @default.
- W2520736812 hasAuthorship W2520736812A5032816263 @default.
- W2520736812 hasAuthorship W2520736812A5040269086 @default.
- W2520736812 hasAuthorship W2520736812A5042397704 @default.
- W2520736812 hasAuthorship W2520736812A5047706524 @default.
- W2520736812 hasAuthorship W2520736812A5069491876 @default.
- W2520736812 hasAuthorship W2520736812A5071002138 @default.
- W2520736812 hasAuthorship W2520736812A5074292766 @default.
- W2520736812 hasAuthorship W2520736812A5084207416 @default.
- W2520736812 hasBestOaLocation W25207368121 @default.
- W2520736812 hasConcept C120770815 @default.
- W2520736812 hasConcept C126322002 @default.
- W2520736812 hasConcept C164705383 @default.
- W2520736812 hasConcept C2777015399 @default.
- W2520736812 hasConcept C2779837120 @default.
- W2520736812 hasConcept C2780868729 @default.
- W2520736812 hasConcept C2993802102 @default.
- W2520736812 hasConcept C42219234 @default.
- W2520736812 hasConcept C71924100 @default.
- W2520736812 hasConcept C84393581 @default.
- W2520736812 hasConcept C89560881 @default.
- W2520736812 hasConcept C98274493 @default.
- W2520736812 hasConceptScore W2520736812C120770815 @default.
- W2520736812 hasConceptScore W2520736812C126322002 @default.
- W2520736812 hasConceptScore W2520736812C164705383 @default.
- W2520736812 hasConceptScore W2520736812C2777015399 @default.
- W2520736812 hasConceptScore W2520736812C2779837120 @default.
- W2520736812 hasConceptScore W2520736812C2780868729 @default.
- W2520736812 hasConceptScore W2520736812C2993802102 @default.
- W2520736812 hasConceptScore W2520736812C42219234 @default.
- W2520736812 hasConceptScore W2520736812C71924100 @default.
- W2520736812 hasConceptScore W2520736812C84393581 @default.
- W2520736812 hasConceptScore W2520736812C89560881 @default.
- W2520736812 hasConceptScore W2520736812C98274493 @default.
- W2520736812 hasLocation W25207368121 @default.
- W2520736812 hasOpenAccess W2520736812 @default.
- W2520736812 hasPrimaryLocation W25207368121 @default.
- W2520736812 hasRelatedWork W1620586541 @default.
- W2520736812 hasRelatedWork W1965999913 @default.
- W2520736812 hasRelatedWork W1969680634 @default.
- W2520736812 hasRelatedWork W1976459707 @default.
- W2520736812 hasRelatedWork W1987283174 @default.
- W2520736812 hasRelatedWork W1994254916 @default.
- W2520736812 hasRelatedWork W2000861544 @default.
- W2520736812 hasRelatedWork W2014528553 @default.
- W2520736812 hasRelatedWork W2023613438 @default.
- W2520736812 hasRelatedWork W2034816682 @default.
- W2520736812 hasRelatedWork W2074111487 @default.
- W2520736812 hasRelatedWork W2074606020 @default.
- W2520736812 hasRelatedWork W2084572764 @default.
- W2520736812 hasRelatedWork W2118995900 @default.
- W2520736812 hasRelatedWork W2125389594 @default.
- W2520736812 hasRelatedWork W2164721180 @default.
- W2520736812 hasRelatedWork W2329584778 @default.
- W2520736812 hasRelatedWork W2411009723 @default.
- W2520736812 hasRelatedWork W2418538706 @default.
- W2520736812 hasRelatedWork W3145867803 @default.
- W2520736812 isParatext "false" @default.
- W2520736812 isRetracted "false" @default.
- W2520736812 magId "2520736812" @default.
- W2520736812 workType "article" @default.