FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2520776985> ?p ?o ?g. }

• W2520776985 abstract "Understanding the early heterotypic interactions between cancer cells and the surrounding non-cancerous stroma is important in elucidating the events leading to stromal activation and establishment of the tumor microenvironment (TME). Several in vitro and in vivo models of the TME have been developed; however, in general these models do not readily permit isolation of individual cell populations, under non-perturbing conditions, for further study. To circumvent this difficulty, we have employed an in vitro TME model using a cell growth substrate consisting of a permeable microporous membrane insert that permits simple generation of highly enriched cell populations grown intimately, yet separately, on either side of the insert's membrane for extended co-culture times. Through use of this model, we are capable of generating greatly enriched cancer-associated fibroblast (CAF) populations from normal diploid human fibroblasts following co-culture (120 hr) with highly metastatic human breast carcinoma cells, without the use of fluorescent tagging and/or cell sorting. Additionally, by modulating the pore-size of the insert, we can control for the mode of intercellular communication (e.g., gap-junction communication, secreted factors) between the two heterotypic cell populations, which permits investigation of the mechanisms underlying the development of the TME, including the role of gap-junction permeability. This model serves as a valuable tool in enhancing our understanding of the initial events leading to cancer-stroma initiation, the early evolution of the TME, and the modulating effect of the stroma on the responses of cancer cells to therapeutic agents." @default.
• W2520776985 created "2016-09-23" @default.
• W2520776985 creator A5013841026 @default.
• W2520776985 creator A5050907579 @default.
• W2520776985 creator A5071465211 @default.
• W2520776985 date "2016-09-20" @default.
• W2520776985 modified "2023-09-26" @default.
• W2520776985 title "A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication" @default.
• W2520776985 cites W1570882372 @default.
• W2520776985 cites W1788413159 @default.
• W2520776985 cites W1848283268 @default.
• W2520776985 cites W1959606306 @default.
• W2520776985 cites W1975543982 @default.
• W2520776985 cites W1977381126 @default.
• W2520776985 cites W1978225946 @default.
• W2520776985 cites W1981898048 @default.
• W2520776985 cites W1988817169 @default.
• W2520776985 cites W1993771380 @default.
• W2520776985 cites W2002545754 @default.
• W2520776985 cites W2003603137 @default.
• W2520776985 cites W2008387441 @default.
• W2520776985 cites W2008881762 @default.
• W2520776985 cites W2012210765 @default.
• W2520776985 cites W2015850084 @default.
• W2520776985 cites W2029712941 @default.
• W2520776985 cites W2034269086 @default.
• W2520776985 cites W2048458549 @default.
• W2520776985 cites W2050031347 @default.
• W2520776985 cites W2054901782 @default.
• W2520776985 cites W2062498782 @default.
• W2520776985 cites W2062909708 @default.
• W2520776985 cites W2065103652 @default.
• W2520776985 cites W2067553572 @default.
• W2520776985 cites W2070779203 @default.
• W2520776985 cites W2072194461 @default.
• W2520776985 cites W2074838406 @default.
• W2520776985 cites W2079899166 @default.
• W2520776985 cites W2082094077 @default.
• W2520776985 cites W2084867240 @default.
• W2520776985 cites W2088551805 @default.
• W2520776985 cites W2093463613 @default.
• W2520776985 cites W2094948118 @default.
• W2520776985 cites W2099530293 @default.
• W2520776985 cites W2101037339 @default.
• W2520776985 cites W2103928688 @default.
• W2520776985 cites W2104416279 @default.
• W2520776985 cites W2105017561 @default.
• W2520776985 cites W2107441200 @default.
• W2520776985 cites W2115759967 @default.
• W2520776985 cites W2119324453 @default.
• W2520776985 cites W2130616535 @default.
• W2520776985 cites W2135114065 @default.
• W2520776985 cites W2136675234 @default.
• W2520776985 cites W2147537177 @default.
• W2520776985 cites W2155755553 @default.
• W2520776985 cites W2166731734 @default.
• W2520776985 cites W2184462655 @default.
• W2520776985 doi "https://doi.org/10.3791/54429" @default.
• W2520776985 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5092054" @default.
• W2520776985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27684198" @default.
• W2520776985 hasPublicationYear "2016" @default.
• W2520776985 type Work @default.
• W2520776985 sameAs 2520776985 @default.
• W2520776985 citedByCount "4" @default.
• W2520776985 countsByYear W25207769852016 @default.
• W2520776985 countsByYear W25207769852017 @default.
• W2520776985 countsByYear W25207769852018 @default.
• W2520776985 crossrefType "journal-article" @default.
• W2520776985 hasAuthorship W2520776985A5013841026 @default.
• W2520776985 hasAuthorship W2520776985A5050907579 @default.
• W2520776985 hasAuthorship W2520776985A5071465211 @default.
• W2520776985 hasBestOaLocation W25207769852 @default.
• W2520776985 hasConcept C121608353 @default.
• W2520776985 hasConcept C1491633281 @default.
• W2520776985 hasConcept C16930146 @default.
• W2520776985 hasConcept C203014093 @default.
• W2520776985 hasConcept C204232928 @default.
• W2520776985 hasConcept C2776107976 @default.
• W2520776985 hasConcept C502942594 @default.
• W2520776985 hasConcept C52124034 @default.
• W2520776985 hasConcept C54355233 @default.
• W2520776985 hasConcept C79879829 @default.
• W2520776985 hasConcept C81885089 @default.
• W2520776985 hasConcept C86803240 @default.
• W2520776985 hasConcept C95444343 @default.
• W2520776985 hasConcept C96232424 @default.
• W2520776985 hasConceptScore W2520776985C121608353 @default.
• W2520776985 hasConceptScore W2520776985C1491633281 @default.
• W2520776985 hasConceptScore W2520776985C16930146 @default.
• W2520776985 hasConceptScore W2520776985C203014093 @default.
• W2520776985 hasConceptScore W2520776985C204232928 @default.
• W2520776985 hasConceptScore W2520776985C2776107976 @default.
• W2520776985 hasConceptScore W2520776985C502942594 @default.
• W2520776985 hasConceptScore W2520776985C52124034 @default.
• W2520776985 hasConceptScore W2520776985C54355233 @default.
• W2520776985 hasConceptScore W2520776985C79879829 @default.
• W2520776985 hasConceptScore W2520776985C81885089 @default.
• W2520776985 hasConceptScore W2520776985C86803240 @default.
• W2520776985 hasConceptScore W2520776985C95444343 @default.
• W2520776985 hasConceptScore W2520776985C96232424 @default.

• next