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• W2520807183 abstract "LORENCONI, R. M. R.; PELAI, E. B.; GODOY, M. F.; DOS SANTOS, A. C. A.; MIYOSHI, L. H.; DE OLIVEIRA, R. N. P.;PADOVANI, C. R.; FREGONESI, C. E. P. T. & CAMARGO FILHO, J. C. S. Histology and renal lipoperoxidation in rats exercisedon a treadmill and submitted to water restriction. Int. J. Morphol., 33(2):660-665, 2015.SUMMARY: Physical effort stimulates an increase in oxygen consumption in tissues, generating toxic chemical species derivedfrom oxygen (ROS), which are considered the initiators of the lipid peroxidation process (LPO), the major mechanism of cellular injury.As the essential mechanism for maintaining the electrolyte balance depends on an effective kidney function, oxidative stress in this organcan be a key factor in the development and persistence of hypertension. This study aimed to determine the kidney changes induce d by acombination of fluid restriction and exercise in rats. The study consisted of 24 male Wistar rats of 90 days of age, divided into fourgroups, two of which were submitted to water restriction and exercise on a treadmill. Twenty-four hours after the last training session,the animals were euthanized and the left kidney was removed. The upper part of the kidney was used for the histological procedur es andthe lower part for the quantification of membrane lipoperoxides. Analysis of variance was applied after testing the normality of data, andthe comparison between groups was performed using the Bonferroni test, adopting a significance of p<0.05. The restriction had aninfluence on body weight; kidney weight; proximal tubule maximum diameter; and area, perimeter and diameter of glomeruli, where asthe exercise affected the weight and the minimum diameter of the proximal tubule. According to the TBARS (thiobarbituric acid r eactivesubstances) method, there was a difference between the G1 (control) and G3 (sedentary with water restriction) and between the G2(exercised with water) and G4 (exercised with water restriction) compared to G1. The treadmill exercise combined with the waterrestriction promoted structural changes in the glomeruli and promoted oxidative stress, although neither variable corroborated for thepotentiating of lipid peroxidation.KEY WORDS: Morphology; Oxidative Stress; Kidney." @default.
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• W2520807183 date "2015-01-01" @default.
• W2520807183 modified "2023-09-26" @default.
• W2520807183 title "Histology and Renal Lipoperoxidation in Rats Exercised on a Treadmill and Submitted to Water Restriction Histología y Lipoperoxidación Renal en Ratas Ejercitadas sobre una Caminadora y Sometidas a Restricción de Agua" @default.
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