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- W2520842278 endingPage "221" @default.
- W2520842278 startingPage "207" @default.
- W2520842278 abstract "Rho GTPases are well known for their roles in regulating cell migration, and also contribute to a variety of other cellular responses. They are subdivided into 2 groups: typical and atypical. The typical Rho family members, including RhoA, Rac1 and Cdc42, cycle between an active GTP-bound and inactive GDP-bound conformation, and are regulated by GEFs, GAPs and GDIs, whereas atypical Rho family members have amino acid substitutions that alter their ability to interact with GTP/GDP and hence are regulated by different mechanisms. Both typical and atypical Rho GTPases contribute to cancer progression. In a few cancers, RhoA or Rac1 are mutated, but in most cancers expression levels and/or activity of Rho GTPases is altered. Rho GTPase signaling could therefore be therapeutically targeted in cancer treatment." @default.
- W2520842278 created "2016-09-23" @default.
- W2520842278 creator A5034325882 @default.
- W2520842278 creator A5052293314 @default.
- W2520842278 date "2016-09-26" @default.
- W2520842278 modified "2023-10-14" @default.
- W2520842278 title "Rho GTPases: Regulation and roles in cancer cell biology" @default.
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