FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2520852005> ?p ?o ?g. }

• W2520852005 endingPage "1558" @default.
• W2520852005 startingPage "1558" @default.
• W2520852005 abstract "The proper functioning of the endoplasmic reticulum (ER) is crucial for multiple cellular activities and survival. Disturbances in the normal ER functions lead to the accumulation and aggregation of unfolded proteins, which initiates an adaptive response, the unfolded protein response (UPR), in order to regain normal ER functions. Failure to activate the adaptive response initiates the process of programmed cell death or apoptosis. Apoptosis plays an important role in cell elimination, which is essential for embryogenesis, development, and tissue homeostasis. Impaired apoptosis can lead to the development of various pathological conditions, such as neurodegenerative and autoimmune diseases, cancer, or acquired immune deficiency syndrome (AIDS). Calcium (Ca2+) is one of the key regulators of cell survival and it can induce ER stress-mediated apoptosis in response to various conditions. Ca2+ regulates cell death both at the early and late stages of apoptosis. Severe Ca2+ dysregulation can promote cell death through apoptosis. Action potential, an electrical signal transmitted along the neurons and muscle fibers, is important for conveying information to, from, and within the brain. Upon the initiation of the action potential, increased levels of cytosolic Ca2+ (depolarization) lead to the activation of the ER stress response involved in the initiation of apoptosis. In this review, we discuss the involvement of Ca2+ and action potential in ER stress-mediated apoptosis." @default.
• W2520852005 created "2016-09-23" @default.
• W2520852005 creator A5013502609 @default.
• W2520852005 creator A5017280494 @default.
• W2520852005 creator A5084238534 @default.
• W2520852005 date "2016-09-15" @default.
• W2520852005 modified "2023-10-09" @default.
• W2520852005 title "ER Stress-Mediated Signaling: Action Potential and Ca2+ as Key Players" @default.
• W2520852005 cites W1044743974 @default.
• W2520852005 cites W11345853 @default.
• W2520852005 cites W1485297825 @default.
• W2520852005 cites W1515343939 @default.
• W2520852005 cites W1522731616 @default.
• W2520852005 cites W1522763255 @default.
• W2520852005 cites W1531356247 @default.
• W2520852005 cites W1535214827 @default.
• W2520852005 cites W1546139069 @default.
• W2520852005 cites W1550247880 @default.
• W2520852005 cites W1566624470 @default.
• W2520852005 cites W1599277155 @default.
• W2520852005 cites W1697178647 @default.
• W2520852005 cites W1758246291 @default.
• W2520852005 cites W1766094056 @default.
• W2520852005 cites W180281116 @default.
• W2520852005 cites W1809311761 @default.
• W2520852005 cites W1884610191 @default.
• W2520852005 cites W1905806846 @default.
• W2520852005 cites W1930219409 @default.
• W2520852005 cites W1949477754 @default.
• W2520852005 cites W1953598538 @default.
• W2520852005 cites W1965727325 @default.
• W2520852005 cites W1965843055 @default.
• W2520852005 cites W1967786181 @default.
• W2520852005 cites W1968112618 @default.
• W2520852005 cites W1968393474 @default.
• W2520852005 cites W1968645668 @default.
• W2520852005 cites W1969690844 @default.
• W2520852005 cites W1970090817 @default.
• W2520852005 cites W1973109581 @default.
• W2520852005 cites W1974795836 @default.
• W2520852005 cites W1975346322 @default.
• W2520852005 cites W1975682391 @default.
• W2520852005 cites W1977603207 @default.
• W2520852005 cites W1978441951 @default.
• W2520852005 cites W1978563221 @default.
• W2520852005 cites W1979091254 @default.
• W2520852005 cites W1979955384 @default.
• W2520852005 cites W1980005294 @default.
• W2520852005 cites W1981503496 @default.
• W2520852005 cites W1982440260 @default.
• W2520852005 cites W1982650516 @default.
• W2520852005 cites W1985339713 @default.
• W2520852005 cites W1986737010 @default.
• W2520852005 cites W1988482079 @default.
• W2520852005 cites W1988777405 @default.
• W2520852005 cites W1989706319 @default.
• W2520852005 cites W1991865867 @default.
• W2520852005 cites W1992604276 @default.
• W2520852005 cites W1994287760 @default.
• W2520852005 cites W1994447752 @default.
• W2520852005 cites W1994575898 @default.
• W2520852005 cites W1996076769 @default.
• W2520852005 cites W1996952569 @default.
• W2520852005 cites W1998626286 @default.
• W2520852005 cites W1999110920 @default.
• W2520852005 cites W2000115025 @default.
• W2520852005 cites W2001399725 @default.
• W2520852005 cites W2002439304 @default.
• W2520852005 cites W2002503549 @default.
• W2520852005 cites W2005866728 @default.
• W2520852005 cites W2008757142 @default.
• W2520852005 cites W2010083809 @default.
• W2520852005 cites W2010454897 @default.
• W2520852005 cites W2012166934 @default.
• W2520852005 cites W2015426350 @default.
• W2520852005 cites W2017291409 @default.
• W2520852005 cites W2020239066 @default.
• W2520852005 cites W2020437934 @default.
• W2520852005 cites W2020916481 @default.
• W2520852005 cites W2021206670 @default.
• W2520852005 cites W2021425674 @default.
• W2520852005 cites W2023397454 @default.
• W2520852005 cites W2025818427 @default.
• W2520852005 cites W2025997346 @default.
• W2520852005 cites W2027490065 @default.
• W2520852005 cites W2028041970 @default.
• W2520852005 cites W2028279477 @default.
• W2520852005 cites W2028974241 @default.
• W2520852005 cites W2029797799 @default.
• W2520852005 cites W2034213169 @default.
• W2520852005 cites W2034327787 @default.
• W2520852005 cites W2036039694 @default.
• W2520852005 cites W2036145275 @default.
• W2520852005 cites W2036677133 @default.
• W2520852005 cites W2040266344 @default.
• W2520852005 cites W2041109703 @default.
• W2520852005 cites W2042494609 @default.
• W2520852005 cites W2046196975 @default.

• next