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- W2520867523 abstract "In the present study chitin nanogel loaded with anti-psoriatic drug clobetasol was developed (CLCNG) for its topical delivery in psoriasis. CLCNG had the particle size of 132 ± 14 nm, with gel like consistency, stability in refrigerator, having higher drug release properties at acidic pH. CLCNG exhibited significant toxicity towards HaCaT and THP-1cell lines by MTT assay. The uptake of nanogel by HaCaT cell lines was confirmed by fluorescent microscopy. CLCNG at 0.35 mg/ml exhibited significant anti-inflammatory activity with an average of 65% and 70% inhibition in COX and LOX activities expressed in THP-1 cells. In vitro skin permeation studies revealed the increased transdermal flux with fragmented stratum corneum and loosened epidermal layers in CLCNG treated samples, compared with control drug solution. The in vivo anti-psoriatic studies done on imiquimod model confirmed the potential benefits of the nanogel for the topical delivery of clobetasol in psoriasis." @default.
- W2520867523 created "2016-09-23" @default.
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- W2520867523 date "2017-01-01" @default.
- W2520867523 modified "2023-10-05" @default.
- W2520867523 title "Comparative anti-psoriatic efficacy studies of clobetasol loaded chitin nanogel and marketed cream" @default.
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- W2520867523 doi "https://doi.org/10.1016/j.ejps.2016.09.007" @default.
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