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- W2520873817 abstract "Several in vitro experimental techniques have been developed to investigate the transport mechanism of drugs across the blood-brain and blood-cerebrospinal fluid barrier. In this article, I summarize the previous transport studies carried out with the isolated and cultured cerebral microvessels, focusing on the transport vector of ligands across the blood-brain barrier. I also describe the transport properties of organic anions snd cations in the isolated choroid plexus, in relation to the role of this tissue in eliminating ligands from the cerebrospinal fluid. The methodology, advantage and limitation of each experimental technique are briefly discussed." @default.
- W2520873817 created "2016-09-23" @default.
- W2520873817 date "1989-01-01" @default.
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- W2520873817 title "In vitro experimental techniques to study the drug transport in the central nervous system." @default.
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- W2520873817 doi "https://doi.org/10.2133/dmpk.4.211" @default.
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