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- W2520919900 abstract "The effects of a novel antianginal agent, molsidomine (N-ethoxycarbonyl-3-morpholinosydnonimine (SIN-10)) and its metabolites (3-morpholinosydnonimine (SIN-1), N-nitroso-N-morpholinoaminoacetonitrile (SIN-1A), cyanomethylenaminomorpholine (SIN-1C) on human platelet aggregation and guanylate cyclase were investigated. SIN-10 and SIN-1C were weak inhibitors of platelet aggregtion induced by collagen (1μg/ml) and ADP (4μM). SIN-1 and SIN-1A were 1, 000 times more potent inhibitors of platelet aggregation than were SIN-10 and SIN-1C. The concentration of SIN-1 and SIN-1A producing 50% inhibition of the platelet aggregation induced by 1μg/ml of collagen were 0.6μM and 0.08μM respectively. SIN-1A was about 10 times more potent inhibitor than SIN-1. Human platelet guanylate cyclase was markedly stimulated by SIN-1 and SIN-1A and half maximal stimulation by these agents were produced by 2μM and 0.2μM, respectively. SIN-10 and SIN-1C did not stimulate the guanylate cyclase activity at concentrations up to 10mM.We now report that the metabolites of SIN-10, such as SIN-1 and SIN-1 A inhibit human platelet aggregation in vitro and also stimulate guanylate cyclase purified from human platelets. Inhibition of platelet aggregation by SIN-10 metabolites may account for a part of their beneficial effects in coronary artery disease." @default.
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- W2520919900 doi "https://doi.org/10.2491/jjsth1970.13.150" @default.
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