FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2520941090> ?p ?o ?g. }

• W2520941090 endingPage "826" @default.
• W2520941090 startingPage "819" @default.
• W2520941090 abstract "Depression induce distressed emotional state and cognitive deficits simultaneously, which both should be improved in the treatment. Hemerocallis citrina Baroni (HC) is a traditional herbal medicine in Eastern-Asia areas and the total phenols extract of HC (HCPE) contains the main active ingredients. It has been reported that HC has the emotional improvement effect. But the cognitive effect of HC was seldom researched. We designed to evaluate the antidepressant and cognitive improvement effect of HCPE using a chronic unpredictable mild stress (CUMS) model, and the potential mechanisms were explored by investigating the corticosterone (CORT), monoamine neurotansmitters, brain-derived neurotropic factor (BDNF) and oxidative stress. The depression rats were induced by CUMS procedures and treated with HCPE (10, 20, 40 mg/kg/day, by gastric gavage). The antidepressant effect was evaluated by sucrose preference test, open field test and body weight, while the cognitive improvement was investigated using morris water maze test. Besides, the levels of monoamine neurotransmitters in the hippocampus and frontal cortex were measured by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). The serum CORT and BDNF in hippocampus were test using enzyme-linked immunosorbent assay (ELISA) kits. The oxidative stress indicators in frontal cortex were also analyzed. HCPE (40 mg/kg) improved the emotion and cognition related behaviors in depression effectively. Moreover, HCPE increased the neurotransmitters concentration (5-HT, DA and NE) in the hippocampus and frontal cortex compared with CUMS rats. Meanwhile, the CUMS induced changes of serum corticosterone level and the hippocampus BDNF level were reversed. Besides, HCPE reduced malondialdehyde (MDA) in the frontal cortex of model rats. It suggested that HCPE could improve the depression-like emotional status and associated cognitive deficits in CUMS rats, which might be mediated by regulation of neurotransmitters and BDNF levels in brain, alleviation of corticosterone level as well as the alleviation of oxidative stress." @default.
• W2520941090 created "2016-09-23" @default.
• W2520941090 creator A5008647141 @default.
• W2520941090 creator A5018353676 @default.
• W2520941090 creator A5020459356 @default.
• W2520941090 creator A5032112054 @default.
• W2520941090 creator A5043345166 @default.
• W2520941090 creator A5043521596 @default.
• W2520941090 creator A5045810332 @default.
• W2520941090 creator A5069055892 @default.
• W2520941090 creator A5088494589 @default.
• W2520941090 date "2016-12-01" @default.
• W2520941090 modified "2023-10-03" @default.
• W2520941090 title "Antidepressant-like effects and cognitive enhancement of the total phenols extract of Hemerocallis citrina Baroni in chronic unpredictable mild stress rats and its related mechanism" @default.
• W2520941090 cites W1972306196 @default.
• W2520941090 cites W1974390576 @default.
• W2520941090 cites W1977291689 @default.
• W2520941090 cites W1977430165 @default.
• W2520941090 cites W1982189983 @default.
• W2520941090 cites W1990354839 @default.
• W2520941090 cites W1990560251 @default.
• W2520941090 cites W1992584151 @default.
• W2520941090 cites W1997728372 @default.
• W2520941090 cites W2003982930 @default.
• W2520941090 cites W2012857169 @default.
• W2520941090 cites W2013122369 @default.
• W2520941090 cites W2023501491 @default.
• W2520941090 cites W2025145340 @default.
• W2520941090 cites W2025834914 @default.
• W2520941090 cites W2041613788 @default.
• W2520941090 cites W2043103881 @default.
• W2520941090 cites W2050758827 @default.
• W2520941090 cites W2054963065 @default.
• W2520941090 cites W2058286264 @default.
• W2520941090 cites W2060018802 @default.
• W2520941090 cites W2066457796 @default.
• W2520941090 cites W2072837658 @default.
• W2520941090 cites W2076277579 @default.
• W2520941090 cites W2078461150 @default.
• W2520941090 cites W2093074337 @default.
• W2520941090 cites W2095395905 @default.
• W2520941090 cites W2098383991 @default.
• W2520941090 cites W2109860355 @default.
• W2520941090 cites W2110310720 @default.
• W2520941090 cites W2110321068 @default.
• W2520941090 cites W2115614479 @default.
• W2520941090 cites W2132324173 @default.
• W2520941090 cites W2134083528 @default.
• W2520941090 cites W2134489176 @default.
• W2520941090 cites W2146111262 @default.
• W2520941090 cites W2151595908 @default.
• W2520941090 cites W2157504436 @default.
• W2520941090 cites W2159223986 @default.
• W2520941090 cites W2166700666 @default.
• W2520941090 cites W2168124527 @default.
• W2520941090 cites W2169473035 @default.
• W2520941090 cites W2314124374 @default.
• W2520941090 cites W2314963372 @default.
• W2520941090 cites W2327573888 @default.
• W2520941090 doi "https://doi.org/10.1016/j.jep.2016.09.023" @default.
• W2520941090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27623554" @default.
• W2520941090 hasPublicationYear "2016" @default.
• W2520941090 type Work @default.
• W2520941090 sameAs 2520941090 @default.
• W2520941090 citedByCount "49" @default.
• W2520941090 countsByYear W25209410902017 @default.
• W2520941090 countsByYear W25209410902018 @default.
• W2520941090 countsByYear W25209410902019 @default.
• W2520941090 countsByYear W25209410902020 @default.
• W2520941090 countsByYear W25209410902021 @default.
• W2520941090 countsByYear W25209410902022 @default.
• W2520941090 countsByYear W25209410902023 @default.
• W2520941090 crossrefType "journal-article" @default.
• W2520941090 hasAuthorship W2520941090A5008647141 @default.
• W2520941090 hasAuthorship W2520941090A5018353676 @default.
• W2520941090 hasAuthorship W2520941090A5020459356 @default.
• W2520941090 hasAuthorship W2520941090A5032112054 @default.
• W2520941090 hasAuthorship W2520941090A5043345166 @default.
• W2520941090 hasAuthorship W2520941090A5043521596 @default.
• W2520941090 hasAuthorship W2520941090A5045810332 @default.
• W2520941090 hasAuthorship W2520941090A5069055892 @default.
• W2520941090 hasAuthorship W2520941090A5088494589 @default.
• W2520941090 hasConcept C126322002 @default.
• W2520941090 hasConcept C134018914 @default.
• W2520941090 hasConcept C136569192 @default.
• W2520941090 hasConcept C15744967 @default.
• W2520941090 hasConcept C170493617 @default.
• W2520941090 hasConcept C185592680 @default.
• W2520941090 hasConcept C187714386 @default.
• W2520941090 hasConcept C2775864247 @default.
• W2520941090 hasConcept C2779085643 @default.
• W2520941090 hasConcept C2779177272 @default.
• W2520941090 hasConcept C2780352252 @default.
• W2520941090 hasConcept C2781161787 @default.
• W2520941090 hasConcept C44752575 @default.
• W2520941090 hasConcept C71315377 @default.
• W2520941090 hasConcept C71924100 @default.
• W2520941090 hasConceptScore W2520941090C126322002 @default.

• next