FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2520957989> ?p ?o ?g. }

• W2520957989 endingPage "13" @default.
• W2520957989 startingPage "1" @default.
• W2520957989 abstract "Bone tissue engineering technique is a promising strategy to repair large-volume bone defects. In this study, we developed a 3-dimensional construct by combining icariin (a small-molecule Chinese medicine), allogeneic bone marrow-derived mesenchymal stem cells (BMSCs), and a siliceous mesostructured cellular foams-poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (SMC-PHBHHx) composite scaffold. We hypothesized that the slowly released icariin could significantly promote the efficacy of SMC-PHBHHx/allogeneic BMSCs for repairing critical-size bone defects in rats. In in vitro cellular experiments, icariin at optimal concentration (10 −6 mol/L) could significantly upregulate the osteogenesis- and angiogenesis-related genes and proteins, such as Runx2, ALP, osteocalcin, vascular endothelial growth factors, and fibroblast growth factors, as well as the mineralization of BMSCs. Icariin that was adsorbed onto the SMC-PHBHHx scaffold showed a slow release profile within a 2-week monitoring span. Eight weeks after implantation in calvarial critical-size bone defects, the constructs with icariin were associated with significantly higher bone volume density, trabecular thickness, trabecular number, and significantly lower trabecular separation than the constructs without icariin. Histomorphometric analysis showed that icariin was also associated with a significantly higher density of newly formed blood vessels. These data suggested a promising application potential of the icariin/SMC-PHBHHx/allogeneic BMSCs constructs for repairing large-volume bone defects in clinic." @default.
• W2520957989 created "2016-09-23" @default.
• W2520957989 creator A5006651636 @default.
• W2520957989 creator A5014355203 @default.
• W2520957989 creator A5045601651 @default.
• W2520957989 creator A5065756853 @default.
• W2520957989 creator A5068275209 @default.
• W2520957989 date "2016-01-01" @default.
• W2520957989 modified "2023-10-15" @default.
• W2520957989 title "Slowly Delivered Icariin/Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells to Promote the Healing of Calvarial Critical-Size Bone Defects" @default.
• W2520957989 cites W1962351050 @default.
• W2520957989 cites W1964985298 @default.
• W2520957989 cites W1965711514 @default.
• W2520957989 cites W1966639987 @default.
• W2520957989 cites W1967348722 @default.
• W2520957989 cites W1974652937 @default.
• W2520957989 cites W1976751326 @default.
• W2520957989 cites W2000132081 @default.
• W2520957989 cites W2013021465 @default.
• W2520957989 cites W2018950607 @default.
• W2520957989 cites W2020246725 @default.
• W2520957989 cites W2022289994 @default.
• W2520957989 cites W2023167090 @default.
• W2520957989 cites W2035653659 @default.
• W2520957989 cites W2041923578 @default.
• W2520957989 cites W2056427474 @default.
• W2520957989 cites W2068752277 @default.
• W2520957989 cites W2068812290 @default.
• W2520957989 cites W2069668213 @default.
• W2520957989 cites W2069864281 @default.
• W2520957989 cites W2070525877 @default.
• W2520957989 cites W2071937786 @default.
• W2520957989 cites W2080378392 @default.
• W2520957989 cites W2083956139 @default.
• W2520957989 cites W2097383766 @default.
• W2520957989 cites W2104162527 @default.
• W2520957989 cites W2104825572 @default.
• W2520957989 cites W2117279278 @default.
• W2520957989 cites W2144201350 @default.
• W2520957989 cites W2145965582 @default.
• W2520957989 cites W2150026598 @default.
• W2520957989 cites W2164961459 @default.
• W2520957989 cites W2171033905 @default.
• W2520957989 cites W2171906614 @default.
• W2520957989 cites W2323664950 @default.
• W2520957989 cites W2338643722 @default.
• W2520957989 cites W2378584282 @default.
• W2520957989 cites W2605187236 @default.
• W2520957989 cites W3000473592 @default.
• W2520957989 cites W31144979 @default.
• W2520957989 cites W4239171241 @default.
• W2520957989 cites W4244095134 @default.
• W2520957989 doi "https://doi.org/10.1155/2016/1416047" @default.
• W2520957989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5040948" @default.
• W2520957989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27721833" @default.
• W2520957989 hasPublicationYear "2016" @default.
• W2520957989 type Work @default.
• W2520957989 sameAs 2520957989 @default.
• W2520957989 citedByCount "16" @default.
• W2520957989 countsByYear W25209579892017 @default.
• W2520957989 countsByYear W25209579892019 @default.
• W2520957989 countsByYear W25209579892021 @default.
• W2520957989 countsByYear W25209579892022 @default.
• W2520957989 countsByYear W25209579892023 @default.
• W2520957989 crossrefType "journal-article" @default.
• W2520957989 hasAuthorship W2520957989A5006651636 @default.
• W2520957989 hasAuthorship W2520957989A5014355203 @default.
• W2520957989 hasAuthorship W2520957989A5045601651 @default.
• W2520957989 hasAuthorship W2520957989A5065756853 @default.
• W2520957989 hasAuthorship W2520957989A5068275209 @default.
• W2520957989 hasBestOaLocation W25209579891 @default.
• W2520957989 hasConcept C104317684 @default.
• W2520957989 hasConcept C105702510 @default.
• W2520957989 hasConcept C126322002 @default.
• W2520957989 hasConcept C131075544 @default.
• W2520957989 hasConcept C136229726 @default.
• W2520957989 hasConcept C142724271 @default.
• W2520957989 hasConcept C160160445 @default.
• W2520957989 hasConcept C16685009 @default.
• W2520957989 hasConcept C181199279 @default.
• W2520957989 hasConcept C185592680 @default.
• W2520957989 hasConcept C198826908 @default.
• W2520957989 hasConcept C199343813 @default.
• W2520957989 hasConcept C202751555 @default.
• W2520957989 hasConcept C204787440 @default.
• W2520957989 hasConcept C2776363554 @default.
• W2520957989 hasConcept C2778260815 @default.
• W2520957989 hasConcept C2780007613 @default.
• W2520957989 hasConcept C2780394083 @default.
• W2520957989 hasConcept C2780426850 @default.
• W2520957989 hasConcept C2780685212 @default.
• W2520957989 hasConcept C30352789 @default.
• W2520957989 hasConcept C49892992 @default.
• W2520957989 hasConcept C55493867 @default.
• W2520957989 hasConcept C71924100 @default.
• W2520957989 hasConcept C8337478 @default.
• W2520957989 hasConcept C86803240 @default.
• W2520957989 hasConcept C88045685 @default.

• next