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• W2520971574 abstract "Two lupane and hopane caffeates (<b>1</b> and <b>4</b>) and two hopane coumarates (<b>2</b> and <b>3</b>) along with eight known compounds (<b>5</b>–<b>12</b>) were isolated from stems and roots of <i>Lepisanthes senegalensis</i>. Their structures were established on the basis of spectroscopic techniques. The structure of compound <b>2</b> was confirmed by single-crystal X-ray diffraction analysis. Triterpenes <b>1</b> and <b>4</b>–<b>6</b> showed cytotoxicity against the NCI-H187 cell line with IC₅₀ values of 31.5, 28.5, 16.2, and 4.0 µM, respectively. However, these compounds also showed cytotoxicity against Vero cells, with IC₅₀ values of 75.5, 16.6, 8.9, and 5.0 µM, respectively. In addition, compound <b>6</b> exhibited a moderate antimalarial activity with an IC₅₀ value of 4.5 µM." @default.
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• W2520971574 date "2016-09-12" @default.
• W2520971574 modified "2023-09-26" @default.
• W2520971574 title "Bioactive Lupane and Hopane Triterpenes from Lepisanthes senegalensis" @default.
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• W2520971574 doi "https://doi.org/10.1055/s-0042-116438" @default.
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