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- W2521004493 abstract "Objective: Recent studies have shown that kidney dysfunction is significantly associated with cognitive dysfunction. However, it is rather difficult to recognize an impairment of cognitive function. We, therefore, investigated whether cystatin C and microalbuminuria, sensitive biomarkers of early renal dysfunction, are more significantly related to cognitive dysfunction than renal dysfunction (low eGFR levels). Design and Method: A total of 1,943 subjects were enrolled, who underwent a health examination in Tanushimaru in 2009. All of them were assessed cognitive function with mini-mental state examination (MMSE). We also measured cystatin C and microalbuminuria levels. Results: The mean levels of log-transformed cystatin C were 0.95 (range 0.4–9.1) mg/l, and log-transformed microalbuminuria levels were 3.61 (range 1.1–937.0) mg/g.Cr. The means of MMSE score were 27.6 ± 2.5. Multivariate regression analyses adjusted for age and gender revealed that systolic BP (p = 0.024, inversely), cystatin C (p = 0.046, inversely), and microalbuminuria (p = 0.016, inversely), whereas, eGFR was not significant (p = 0.250). In the multiple logistic regression analyses adjusted for age and gender, the significance of microalbumiuria with MMSE was still remained (odds ratio: 1.251; 95%CI: 1.052–1.486; p = 0.016). Conclusions: We demonstrated for the first time that cognitive function was significantly and inversely associated with microalbuminuria and cystatin C and rather than eGFR in the general population." @default.
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- W2521004493 date "2016-09-01" @default.
- W2521004493 modified "2023-10-16" @default.
- W2521004493 title "PS 09-21 IMPACT OF CYSTATIN C AND MICROALBUMINURIA ON COGNITIVE DYSFUNCTION IN THE POPULATION OF COMMUNITY-DWELLING JAPANESE" @default.
- W2521004493 doi "https://doi.org/10.1097/01.hjh.0000500800.62570.ba" @default.
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