Matches in SemOpenAlex for { <https://semopenalex.org/work/W2521028081> ?p ?o ?g. }
- W2521028081 endingPage "68" @default.
- W2521028081 startingPage "62" @default.
- W2521028081 abstract "Fibroblast growth factor-23 (FGF23) is a bone-derived hormone protecting against the potentially deleterious effects of hyperphosphatemia by suppression of phosphate reabsorption and of active vitamin D hormone synthesis in the kidney. The kidney is one of the main target organs of FGF23 signaling. The purpose of this review is to highlight the recent advances in the area of FGF23-Klotho signaling in the kidney. During recent years, it has become clear that FGF23 acts independently on proximal and distal tubular epithelium. In proximal renal tubules, FGF23 suppresses phosphate reabsorption by a Klotho dependent activation of extracellular signal-regulated kinase-1/2 (ERK1/2) and of serum/glucocorticoid-regulated kinase-1 (SGK1), leading to phosphorylation of the scaffolding protein Na+/H+ exchange regulatory cofactor (NHERF)-1 and subsequent internalization and degradation of sodium-phosphate cotransporters. In distal renal tubules, FGF23 augments calcium and sodium reabsorption by increasing the apical membrane expression of the epithelial calcium channel TRPV5 and of the sodium-chloride cotransporter NCC through a Klotho dependent activation of with-no-lysine kinase-4 (WNK4). In proximal and distal renal tubules, FGF receptor-1 is probably the dominant FGF receptor mediating the effects of FGF23 by forming a complex with membrane-bound Klotho in the basolateral membrane. The newly described sodium- and calcium-conserving functions of FGF23 may have major implications for the pathophysiology of diseases characterized by chronically increased circulating FGF23 concentrations such as chronic kidney disease." @default.
- W2521028081 created "2016-09-23" @default.
- W2521028081 creator A5052931841 @default.
- W2521028081 creator A5062610054 @default.
- W2521028081 date "2017-07-01" @default.
- W2521028081 modified "2023-10-16" @default.
- W2521028081 title "FGF23-Klotho signaling axis in the kidney" @default.
- W2521028081 cites W1509037082 @default.
- W2521028081 cites W1563425273 @default.
- W2521028081 cites W1902909046 @default.
- W2521028081 cites W1963923603 @default.
- W2521028081 cites W1963936842 @default.
- W2521028081 cites W1965943515 @default.
- W2521028081 cites W1977518774 @default.
- W2521028081 cites W1978131786 @default.
- W2521028081 cites W1978759455 @default.
- W2521028081 cites W1982498018 @default.
- W2521028081 cites W1999372562 @default.
- W2521028081 cites W2000513641 @default.
- W2521028081 cites W2002494594 @default.
- W2521028081 cites W2007850369 @default.
- W2521028081 cites W2008643011 @default.
- W2521028081 cites W2015439084 @default.
- W2521028081 cites W2015599341 @default.
- W2521028081 cites W2015668150 @default.
- W2521028081 cites W2019551545 @default.
- W2521028081 cites W2019620862 @default.
- W2521028081 cites W2021852822 @default.
- W2521028081 cites W2027479037 @default.
- W2521028081 cites W2028480953 @default.
- W2521028081 cites W2034534512 @default.
- W2521028081 cites W2038558843 @default.
- W2521028081 cites W2044685565 @default.
- W2521028081 cites W2046983926 @default.
- W2521028081 cites W2047424940 @default.
- W2521028081 cites W2054195724 @default.
- W2521028081 cites W2059512273 @default.
- W2521028081 cites W2061453367 @default.
- W2521028081 cites W2066517300 @default.
- W2521028081 cites W2073073612 @default.
- W2521028081 cites W2078382957 @default.
- W2521028081 cites W2079813075 @default.
- W2521028081 cites W2082302029 @default.
- W2521028081 cites W2083288593 @default.
- W2521028081 cites W2091948921 @default.
- W2521028081 cites W2095938777 @default.
- W2521028081 cites W2105398326 @default.
- W2521028081 cites W2106711282 @default.
- W2521028081 cites W2114309748 @default.
- W2521028081 cites W2114360920 @default.
- W2521028081 cites W2114372930 @default.
- W2521028081 cites W2114781384 @default.
- W2521028081 cites W2121270324 @default.
- W2521028081 cites W2125093965 @default.
- W2521028081 cites W2127396817 @default.
- W2521028081 cites W2128059069 @default.
- W2521028081 cites W2129321769 @default.
- W2521028081 cites W2131064361 @default.
- W2521028081 cites W2132961875 @default.
- W2521028081 cites W2133492406 @default.
- W2521028081 cites W2139600905 @default.
- W2521028081 cites W2139989191 @default.
- W2521028081 cites W2147678196 @default.
- W2521028081 cites W2148382170 @default.
- W2521028081 cites W2152732984 @default.
- W2521028081 cites W2154287224 @default.
- W2521028081 cites W2154354301 @default.
- W2521028081 cites W2161470994 @default.
- W2521028081 cites W2164533721 @default.
- W2521028081 cites W2167995070 @default.
- W2521028081 cites W2168867186 @default.
- W2521028081 cites W2169020430 @default.
- W2521028081 cites W2170351820 @default.
- W2521028081 cites W2171810233 @default.
- W2521028081 cites W2172119923 @default.
- W2521028081 cites W2180550475 @default.
- W2521028081 cites W2180931521 @default.
- W2521028081 cites W2292291307 @default.
- W2521028081 cites W2294844169 @default.
- W2521028081 cites W2322370459 @default.
- W2521028081 cites W2398878553 @default.
- W2521028081 cites W2412505484 @default.
- W2521028081 cites W2466307295 @default.
- W2521028081 cites W2498376032 @default.
- W2521028081 cites W4245958271 @default.
- W2521028081 doi "https://doi.org/10.1016/j.bone.2016.09.010" @default.
- W2521028081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27622885" @default.
- W2521028081 hasPublicationYear "2017" @default.
- W2521028081 type Work @default.
- W2521028081 sameAs 2521028081 @default.
- W2521028081 citedByCount "107" @default.
- W2521028081 countsByYear W25210280812016 @default.
- W2521028081 countsByYear W25210280812017 @default.
- W2521028081 countsByYear W25210280812018 @default.
- W2521028081 countsByYear W25210280812019 @default.
- W2521028081 countsByYear W25210280812020 @default.
- W2521028081 countsByYear W25210280812021 @default.
- W2521028081 countsByYear W25210280812022 @default.