FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2521080956> ?p ?o ?g. }

• W2521080956 abstract "Abstract TRAF2- and NCK-interacting kinase (TNIK) represents one of the crucial targets for Wnt-activated colorectal cancer. In this study, we curated two datasets and conducted a comprehensive modeling study to explore novel TNIK inhibitors with desirable biopharmaceutical properties. With Dataset I, we derived Comparative Molecular Similarity Indices Analysis (CoMSIA) and variable-selection k-nearest neighbor models, from which 3D-molecular fields and 2D-descriptors critical for the TNIK inhibitor activity were revealed. Based on Dataset II, predictive CoMSIA-SIMCA (Soft Independent Modelling by Class Analogy) models were obtained and employed to screen 1,448 FDA-approved small molecule drugs. Upon experimental evaluations, we discovered that mebendazole, an approved anthelmintic drug, could selectively inhibit TNIK kinase activity with a dissociation constant K d = ~1 μM. The subsequent CoMSIA and kNN analyses indicated that mebendazole bears the favorable molecular features that are needed to bind and inhibit TNIK." @default.
• W2521080956 created "2016-09-30" @default.
• W2521080956 creator A5024508027 @default.
• W2521080956 creator A5074466112 @default.
• W2521080956 creator A5088496837 @default.
• W2521080956 date "2016-09-21" @default.
• W2521080956 modified "2023-09-27" @default.
• W2521080956 title "Comprehensive Modeling and Discovery of Mebendazole as a Novel TRAF2- and NCK-interacting Kinase Inhibitor" @default.
• W2521080956 cites W1571439140 @default.
• W2521080956 cites W1971258489 @default.
• W2521080956 cites W1983790923 @default.
• W2521080956 cites W1984308718 @default.
• W2521080956 cites W1986168751 @default.
• W2521080956 cites W1992127683 @default.
• W2521080956 cites W2002503643 @default.
• W2521080956 cites W2009923630 @default.
• W2521080956 cites W2013126815 @default.
• W2521080956 cites W2014582878 @default.
• W2521080956 cites W2016538937 @default.
• W2521080956 cites W2022885475 @default.
• W2521080956 cites W2023206317 @default.
• W2521080956 cites W2032578973 @default.
• W2521080956 cites W2043605426 @default.
• W2521080956 cites W2050819809 @default.
• W2521080956 cites W2052030759 @default.
• W2521080956 cites W2064565588 @default.
• W2521080956 cites W2071506358 @default.
• W2521080956 cites W2077804275 @default.
• W2521080956 cites W2079398727 @default.
• W2521080956 cites W2083497194 @default.
• W2521080956 cites W2084517238 @default.
• W2521080956 cites W2086286404 @default.
• W2521080956 cites W2088844236 @default.
• W2521080956 cites W2103084538 @default.
• W2521080956 cites W2104452138 @default.
• W2521080956 cites W2112099875 @default.
• W2521080956 cites W2120071860 @default.
• W2521080956 cites W2122008242 @default.
• W2521080956 cites W2124275237 @default.
• W2521080956 cites W2137052779 @default.
• W2521080956 cites W2154142433 @default.
• W2521080956 cites W2171910732 @default.
• W2521080956 cites W2172019818 @default.
• W2521080956 cites W2346292862 @default.
• W2521080956 cites W2478269152 @default.
• W2521080956 doi "https://doi.org/10.1038/srep33534" @default.
• W2521080956 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5030704" @default.
• W2521080956 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27650168" @default.
• W2521080956 hasPublicationYear "2016" @default.
• W2521080956 type Work @default.
• W2521080956 sameAs 2521080956 @default.
• W2521080956 citedByCount "28" @default.
• W2521080956 countsByYear W25210809562017 @default.
• W2521080956 countsByYear W25210809562018 @default.
• W2521080956 countsByYear W25210809562019 @default.
• W2521080956 countsByYear W25210809562020 @default.
• W2521080956 countsByYear W25210809562021 @default.
• W2521080956 countsByYear W25210809562022 @default.
• W2521080956 countsByYear W25210809562023 @default.
• W2521080956 crossrefType "journal-article" @default.
• W2521080956 hasAuthorship W2521080956A5024508027 @default.
• W2521080956 hasAuthorship W2521080956A5074466112 @default.
• W2521080956 hasAuthorship W2521080956A5088496837 @default.
• W2521080956 hasBestOaLocation W25210809561 @default.
• W2521080956 hasConcept C104317684 @default.
• W2521080956 hasConcept C105795698 @default.
• W2521080956 hasConcept C137620995 @default.
• W2521080956 hasConcept C161624437 @default.
• W2521080956 hasConcept C184235292 @default.
• W2521080956 hasConcept C185592680 @default.
• W2521080956 hasConcept C18903297 @default.
• W2521080956 hasConcept C27158222 @default.
• W2521080956 hasConcept C2779061029 @default.
• W2521080956 hasConcept C33923547 @default.
• W2521080956 hasConcept C41008148 @default.
• W2521080956 hasConcept C502942594 @default.
• W2521080956 hasConcept C55493867 @default.
• W2521080956 hasConcept C60644358 @default.
• W2521080956 hasConcept C70721500 @default.
• W2521080956 hasConcept C74187038 @default.
• W2521080956 hasConcept C86803240 @default.
• W2521080956 hasConceptScore W2521080956C104317684 @default.
• W2521080956 hasConceptScore W2521080956C105795698 @default.
• W2521080956 hasConceptScore W2521080956C137620995 @default.
• W2521080956 hasConceptScore W2521080956C161624437 @default.
• W2521080956 hasConceptScore W2521080956C184235292 @default.
• W2521080956 hasConceptScore W2521080956C185592680 @default.
• W2521080956 hasConceptScore W2521080956C18903297 @default.
• W2521080956 hasConceptScore W2521080956C27158222 @default.
• W2521080956 hasConceptScore W2521080956C2779061029 @default.
• W2521080956 hasConceptScore W2521080956C33923547 @default.
• W2521080956 hasConceptScore W2521080956C41008148 @default.
• W2521080956 hasConceptScore W2521080956C502942594 @default.
• W2521080956 hasConceptScore W2521080956C55493867 @default.
• W2521080956 hasConceptScore W2521080956C60644358 @default.
• W2521080956 hasConceptScore W2521080956C70721500 @default.
• W2521080956 hasConceptScore W2521080956C74187038 @default.
• W2521080956 hasConceptScore W2521080956C86803240 @default.
• W2521080956 hasIssue "1" @default.
• W2521080956 hasLocation W25210809561 @default.

• next