Matches in SemOpenAlex for { <https://semopenalex.org/work/W2521100604> ?p ?o ?g. }
- W2521100604 abstract "Abstract The metabolic machinery for the biosynthesis of Coenzyme A (CoA) from exogenous pantothenic acid (Vitamin B 5 ) has long been considered as an excellent target for the development of selective antimicrobials. Earlier studies in the human malaria parasite Plasmodium falciparum have shown that pantothenate analogs interfere with pantothenate phosphorylation and block asexual blood stage development. Although two eukaryotic-type putative pantothenate kinase genes ( PanK1 and PanK2 ) have been identified in all malaria parasite species, their role in the development of Plasmodium life cycle stages remains unknown. Here we report on the genetic characterization of PanK1 and PanK2 in P. yoelii . We show that P. yoelii parasites lacking either PanK1 or PanK2 undergo normal asexual stages development and sexual stages differentiation, however they are severely deficient in ookinete, oocyst and sporozoite formation inside the mosquito vector. Quantitative transcriptional analyses in wild-type and knockout parasites demonstrate an important role for these genes in the regulation of expression of other CoA biosynthesis genes. Together, our data provide the first genetic evidence for the importance of the early steps of pantothenate utilization in the regulation of CoA biosynthesis and malaria parasite transmission to Anopheles mosquitoes." @default.
- W2521100604 created "2016-09-30" @default.
- W2521100604 creator A5005693657 @default.
- W2521100604 creator A5008481640 @default.
- W2521100604 creator A5010911294 @default.
- W2521100604 creator A5025444724 @default.
- W2521100604 creator A5025999523 @default.
- W2521100604 creator A5044988737 @default.
- W2521100604 creator A5051342709 @default.
- W2521100604 date "2016-09-20" @default.
- W2521100604 modified "2023-10-01" @default.
- W2521100604 title "Genetic Characterization of Plasmodium Putative Pantothenate Kinase Genes Reveals Their Essential Role in Malaria Parasite Transmission to the Mosquito" @default.
- W2521100604 cites W1483232094 @default.
- W2521100604 cites W1576233700 @default.
- W2521100604 cites W1590488513 @default.
- W2521100604 cites W1597638835 @default.
- W2521100604 cites W1602119380 @default.
- W2521100604 cites W1633281479 @default.
- W2521100604 cites W1963957860 @default.
- W2521100604 cites W1973451419 @default.
- W2521100604 cites W1975835797 @default.
- W2521100604 cites W2004798786 @default.
- W2521100604 cites W2017531223 @default.
- W2521100604 cites W2017652283 @default.
- W2521100604 cites W2019071017 @default.
- W2521100604 cites W2019879105 @default.
- W2521100604 cites W2020975692 @default.
- W2521100604 cites W2021610941 @default.
- W2521100604 cites W2022738557 @default.
- W2521100604 cites W2024290332 @default.
- W2521100604 cites W2029055174 @default.
- W2521100604 cites W2034200810 @default.
- W2521100604 cites W2034490768 @default.
- W2521100604 cites W2040611232 @default.
- W2521100604 cites W2044944379 @default.
- W2521100604 cites W2047517357 @default.
- W2521100604 cites W2055043387 @default.
- W2521100604 cites W2060579679 @default.
- W2521100604 cites W2062181273 @default.
- W2521100604 cites W2074378087 @default.
- W2521100604 cites W2085462579 @default.
- W2521100604 cites W2088466434 @default.
- W2521100604 cites W2096833675 @default.
- W2521100604 cites W2098778969 @default.
- W2521100604 cites W2103546861 @default.
- W2521100604 cites W2109551540 @default.
- W2521100604 cites W2123571066 @default.
- W2521100604 cites W2131213425 @default.
- W2521100604 cites W2147526198 @default.
- W2521100604 cites W2152727028 @default.
- W2521100604 cites W2168284706 @default.
- W2521100604 cites W2170017808 @default.
- W2521100604 cites W2276884270 @default.
- W2521100604 cites W2397350157 @default.
- W2521100604 cites W2463442958 @default.
- W2521100604 cites W2739999456 @default.
- W2521100604 doi "https://doi.org/10.1038/srep33518" @default.
- W2521100604 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5028760" @default.
- W2521100604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27644319" @default.
- W2521100604 hasPublicationYear "2016" @default.
- W2521100604 type Work @default.
- W2521100604 sameAs 2521100604 @default.
- W2521100604 citedByCount "21" @default.
- W2521100604 countsByYear W25211006042017 @default.
- W2521100604 countsByYear W25211006042018 @default.
- W2521100604 countsByYear W25211006042019 @default.
- W2521100604 countsByYear W25211006042020 @default.
- W2521100604 countsByYear W25211006042021 @default.
- W2521100604 countsByYear W25211006042022 @default.
- W2521100604 countsByYear W25211006042023 @default.
- W2521100604 crossrefType "journal-article" @default.
- W2521100604 hasAuthorship W2521100604A5005693657 @default.
- W2521100604 hasAuthorship W2521100604A5008481640 @default.
- W2521100604 hasAuthorship W2521100604A5010911294 @default.
- W2521100604 hasAuthorship W2521100604A5025444724 @default.
- W2521100604 hasAuthorship W2521100604A5025999523 @default.
- W2521100604 hasAuthorship W2521100604A5044988737 @default.
- W2521100604 hasAuthorship W2521100604A5051342709 @default.
- W2521100604 hasBestOaLocation W25211006041 @default.
- W2521100604 hasConcept C104317684 @default.
- W2521100604 hasConcept C136764020 @default.
- W2521100604 hasConcept C203014093 @default.
- W2521100604 hasConcept C2775867548 @default.
- W2521100604 hasConcept C2776486806 @default.
- W2521100604 hasConcept C2778048844 @default.
- W2521100604 hasConcept C2778371730 @default.
- W2521100604 hasConcept C2778675580 @default.
- W2521100604 hasConcept C2781375639 @default.
- W2521100604 hasConcept C41008148 @default.
- W2521100604 hasConcept C54355233 @default.
- W2521100604 hasConcept C71928629 @default.
- W2521100604 hasConcept C86803240 @default.
- W2521100604 hasConceptScore W2521100604C104317684 @default.
- W2521100604 hasConceptScore W2521100604C136764020 @default.
- W2521100604 hasConceptScore W2521100604C203014093 @default.
- W2521100604 hasConceptScore W2521100604C2775867548 @default.
- W2521100604 hasConceptScore W2521100604C2776486806 @default.
- W2521100604 hasConceptScore W2521100604C2778048844 @default.
- W2521100604 hasConceptScore W2521100604C2778371730 @default.
- W2521100604 hasConceptScore W2521100604C2778675580 @default.