FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2521142983> ?p ?o ?g. }

• W2521142983 endingPage "99" @default.
• W2521142983 startingPage "89" @default.
• W2521142983 abstract "Depression has been linked to disruption in the cerebral levels of specific neurotransmitters. L-tyrosine is a precursor of more than one of the neurotransmitters affected by depression. Even though setbacks of monoamines precursors include high doses and low efficiency, many studies have suggested using L-tyrosine as antidepressant.The purpose of this study was to explore the possible antidepressant effect of L-tyrosine loaded in a nanoparticle-designed formula, using behavioral tests in acute and chronic mild stress (CMS) models of depression in rats.Animals from both models received L-tyrosine-loaded nanoparticles (5 or 10 mg/kg), L-tyrosine solution (10 mg/kg), fluoxetine (10 mg/kg) or placebo daily for 21 days. Rats from the acute stress model of depression were subjected to open field and forced swim tests (FSTs). For the CMS model, sucrose preference test was carried out. Additionally, 3 profiles of the nanoparticles formula were tested in vitro. High dissolution rate and entrapment efficiency were obtained from the in vitro tests. Moreover, L-tyrosine-loaded nanoparticles 10 mg/kg and fluoxetine 10 mg/kg significantly decreased the immobility time in the FST, concomitant with restoration of the basal levels of locomotor activity, distance travelled and rearing counts. Also, an increase of the sucrose consumption was recorded in the sucrose preference test after treatment with L-tyrosine-loaded nanoparticles 10 mg/kg and fluoxetine 10 mg/kg.The positive results after treatment with L-tyrosine-loaded nanoparticles, through behavioral tests, are probably attributed to restorating the basal levels of the cerebral noradrenaline.The effects of L-tyrosine administration on the cerebral levels of tyrosine hydroxylase and corticotropin-releasing factor should be further investigated." @default.
• W2521142983 created "2016-09-30" @default.
• W2521142983 creator A5000689551 @default.
• W2521142983 creator A5033239676 @default.
• W2521142983 creator A5067221015 @default.
• W2521142983 date "2016-01-01" @default.
• W2521142983 modified "2023-09-25" @default.
• W2521142983 title "The Antidepressant Effect of L-Tyrosine-Loaded Nanoparticles: Behavioral Aspects" @default.
• W2521142983 cites W1677460581 @default.
• W2521142983 cites W1687818306 @default.
• W2521142983 cites W1968235275 @default.
• W2521142983 cites W1975495109 @default.
• W2521142983 cites W1977430165 @default.
• W2521142983 cites W1982695460 @default.
• W2521142983 cites W1987491785 @default.
• W2521142983 cites W1988574111 @default.
• W2521142983 cites W2000001045 @default.
• W2521142983 cites W2000413453 @default.
• W2521142983 cites W2005404444 @default.
• W2521142983 cites W2009278722 @default.
• W2521142983 cites W2011005493 @default.
• W2521142983 cites W2013598219 @default.
• W2521142983 cites W2015879934 @default.
• W2521142983 cites W2016605917 @default.
• W2521142983 cites W2023507956 @default.
• W2521142983 cites W2023576244 @default.
• W2521142983 cites W2026344745 @default.
• W2521142983 cites W2031746321 @default.
• W2521142983 cites W2042335899 @default.
• W2521142983 cites W2050836998 @default.
• W2521142983 cites W2051796892 @default.
• W2521142983 cites W2053472601 @default.
• W2521142983 cites W2055380400 @default.
• W2521142983 cites W2055447689 @default.
• W2521142983 cites W2058410379 @default.
• W2521142983 cites W2059784555 @default.
• W2521142983 cites W2060982579 @default.
• W2521142983 cites W2061662801 @default.
• W2521142983 cites W2066457796 @default.
• W2521142983 cites W2068292018 @default.
• W2521142983 cites W2072005245 @default.
• W2521142983 cites W2079785069 @default.
• W2521142983 cites W2088919174 @default.
• W2521142983 cites W2089299823 @default.
• W2521142983 cites W2089716345 @default.
• W2521142983 cites W2089863147 @default.
• W2521142983 cites W2094205061 @default.
• W2521142983 cites W2095411534 @default.
• W2521142983 cites W2096856326 @default.
• W2521142983 cites W2134135893 @default.
• W2521142983 cites W2135782311 @default.
• W2521142983 cites W2154085228 @default.
• W2521142983 cites W2159202946 @default.
• W2521142983 cites W2186663297 @default.
• W2521142983 cites W2337295397 @default.
• W2521142983 cites W2484260316 @default.
• W2521142983 cites W3022052974 @default.
• W2521142983 cites W32065294 @default.
• W2521142983 doi "https://doi.org/10.1159/000443575" @default.
• W2521142983 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5020390" @default.
• W2521142983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27647959" @default.
• W2521142983 hasPublicationYear "2016" @default.
• W2521142983 type Work @default.
• W2521142983 sameAs 2521142983 @default.
• W2521142983 citedByCount "12" @default.
• W2521142983 countsByYear W25211429832019 @default.
• W2521142983 countsByYear W25211429832020 @default.
• W2521142983 countsByYear W25211429832021 @default.
• W2521142983 countsByYear W25211429832022 @default.
• W2521142983 countsByYear W25211429832023 @default.
• W2521142983 crossrefType "journal-article" @default.
• W2521142983 hasAuthorship W2521142983A5000689551 @default.
• W2521142983 hasAuthorship W2521142983A5033239676 @default.
• W2521142983 hasAuthorship W2521142983A5067221015 @default.
• W2521142983 hasBestOaLocation W25211429831 @default.
• W2521142983 hasConcept C126322002 @default.
• W2521142983 hasConcept C134018914 @default.
• W2521142983 hasConcept C136569192 @default.
• W2521142983 hasConcept C142724271 @default.
• W2521142983 hasConcept C155672457 @default.
• W2521142983 hasConcept C170493617 @default.
• W2521142983 hasConcept C171250308 @default.
• W2521142983 hasConcept C185592680 @default.
• W2521142983 hasConcept C187714386 @default.
• W2521142983 hasConcept C192562407 @default.
• W2521142983 hasConcept C202751555 @default.
• W2521142983 hasConcept C204787440 @default.
• W2521142983 hasConcept C27081682 @default.
• W2521142983 hasConcept C2775864247 @default.
• W2521142983 hasConcept C2776134451 @default.
• W2521142983 hasConcept C2776165026 @default.
• W2521142983 hasConcept C2778024521 @default.
• W2521142983 hasConcept C2778597767 @default.
• W2521142983 hasConcept C2779085643 @default.
• W2521142983 hasConcept C2779177272 @default.
• W2521142983 hasConcept C2781161787 @default.
• W2521142983 hasConcept C55493867 @default.
• W2521142983 hasConcept C555293320 @default.

• next