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• W2521152128 abstract "Preclinical studies with IL-12 in animal models of experimental oncology have shown very encouraging results and acceptable toxicities and prompted the use of IL-12 in cancer patients in the mid-90s of the last century. On the basis of the largest registry of clinical studies in the world ( http://www.clinicaltrials.gov ), 58 clinical trials, in which IL-12-based therapy was/is used for treatment of patients with various types of cancers (key words for survey: IL-12, interleukin 12, hIL-12, pIL-12, INO-9012, tumor, cancer) have been identified so far. Analysis the history of these trials shows three stages of interest in the application of IL-12 in clinical oncology. Years 1996–2005 was a period of most intensive studies in which optimal treatment schedules, maximal tolerated doses of IL-12, and the most susceptible tumors were characterized. IL-12 was had a very narrow therapeutic index and its systemic administration induced severe side effects. In fact, only few studies reported promising results with sporadic overt tumor regressions (apart from patients with AIDS-associated Kaposi sarcoma). Due to the low response to IL-12 and its high toxicity, accrual to some trials was even stopped (Motzer et al. in Journal of Interferon and Cytokine Research 21:257–263, 2001). However, after a several-year discouragement in the first decade of this century it seems that the interest in therapeutic potential of IL-12 has revived but the strategy of its use is being revised. Generally, IL-12-based therapies can be divided into three categories: While the first approach predominated in years 1996–2005, most of the recently initiated clinical trials have been concentrated on gene therapy (Fig. 3.1) (Lasek et al. in Cancer Immunology Immunotherapy 63(5):419–435, 2014). At present, twenty five IL-12-based clinical trials in cancer patients are ongoing/active (as of July 1, 2016)." @default.
• W2521152128 created "2016-09-30" @default.
• W2521152128 creator A5050488184 @default.
• W2521152128 creator A5066081320 @default.
• W2521152128 date "2016-01-01" @default.
• W2521152128 modified "2023-10-16" @default.
• W2521152128 title "Clinical Trials with IL-12 in Cancer Immunotherapy" @default.
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