FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2521178821> ?p ?o ?g. }

• W2521178821 endingPage "1835" @default.
• W2521178821 startingPage "1823" @default.
• W2521178821 abstract "p97 is a protein complex of the AAA+ family. Although functions of p97 are well understood, the mechanism by which p97 performs its unfolding activities remains unclear. In this work, we present a novel way of applying normal mode analysis to study this six-fold symmetric molecular machine. By selecting normal modes that are axial symmetric and give the largest movements at D1 or D2 pore residues, we are able to predict the functional motions of p97, which are then validated by experimentally observed conformational changes. Our results shed light and provide new understandings on several key steps of the p97 functional process that were previously unclear or controversial, and thus are able to reconcile multiple previous findings. Specifically, our results reveal that (i) a venous valve-like mechanism is used at D2 pore to ensure a one-way exit-only traffic of substrates; (ii) D1 pore remains shut during the functional process; (iii) the swing-up motion of the N domain is closely coupled with the vertical motion of the D1 pore along the pore axis; (iv) because of the shut D1 pore and the one-way traffic at D2 pore, it is highly likely that substrates enter the chamber through the gaps at the D1/D2 interface. The limited chamber volume inside p97 suggests that a substrate may be pulling out from D2 while at the same time being pulling in at the interface; (v) lastly, p97 uses a series of actions that alternate between twisting and pulling to remove the substrate. Proteins 2016; 84:1823-1835. © 2016 Wiley Periodicals, Inc." @default.
• W2521178821 created "2016-09-30" @default.
• W2521178821 creator A5070788254 @default.
• W2521178821 creator A5081862540 @default.
• W2521178821 date "2016-10-01" @default.
• W2521178821 modified "2023-10-11" @default.
• W2521178821 title "Predicting the functional motions of p97 using symmetric normal modes" @default.
• W2521178821 cites W1954990078 @default.
• W2521178821 cites W1974031565 @default.
• W2521178821 cites W1987262921 @default.
• W2521178821 cites W1989587195 @default.
• W2521178821 cites W1990890893 @default.
• W2521178821 cites W1991976083 @default.
• W2521178821 cites W1997310186 @default.
• W2521178821 cites W2003079343 @default.
• W2521178821 cites W2011790784 @default.
• W2521178821 cites W2029667189 @default.
• W2521178821 cites W2032565934 @default.
• W2521178821 cites W2033088972 @default.
• W2521178821 cites W2047634825 @default.
• W2521178821 cites W2059265460 @default.
• W2521178821 cites W2062950273 @default.
• W2521178821 cites W2070487248 @default.
• W2521178821 cites W2070863543 @default.
• W2521178821 cites W2078813054 @default.
• W2521178821 cites W2088906583 @default.
• W2521178821 cites W2091667355 @default.
• W2521178821 cites W2092103430 @default.
• W2521178821 cites W2099327491 @default.
• W2521178821 cites W2106461761 @default.
• W2521178821 cites W2113994268 @default.
• W2521178821 cites W2118755520 @default.
• W2521178821 cites W2120193453 @default.
• W2521178821 cites W2130479394 @default.
• W2521178821 cites W2135908828 @default.
• W2521178821 cites W2137825366 @default.
• W2521178821 cites W2141284487 @default.
• W2521178821 cites W2146969978 @default.
• W2521178821 cites W2155512297 @default.
• W2521178821 cites W2160789725 @default.
• W2521178821 cites W2184159865 @default.
• W2521178821 cites W2216848450 @default.
• W2521178821 cites W2259068415 @default.
• W2521178821 cites W2262570813 @default.
• W2521178821 cites W2263982485 @default.
• W2521178821 cites W2355503950 @default.
• W2521178821 doi "https://doi.org/10.1002/prot.25164" @default.
• W2521178821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27653958" @default.
• W2521178821 hasPublicationYear "2016" @default.
• W2521178821 type Work @default.
• W2521178821 sameAs 2521178821 @default.
• W2521178821 citedByCount "15" @default.
• W2521178821 countsByYear W25211788212016 @default.
• W2521178821 countsByYear W25211788212017 @default.
• W2521178821 countsByYear W25211788212018 @default.
• W2521178821 countsByYear W25211788212019 @default.
• W2521178821 countsByYear W25211788212020 @default.
• W2521178821 countsByYear W25211788212023 @default.
• W2521178821 crossrefType "journal-article" @default.
• W2521178821 hasAuthorship W2521178821A5070788254 @default.
• W2521178821 hasAuthorship W2521178821A5081862540 @default.
• W2521178821 hasConcept C104114177 @default.
• W2521178821 hasConcept C111368507 @default.
• W2521178821 hasConcept C111919701 @default.
• W2521178821 hasConcept C121332964 @default.
• W2521178821 hasConcept C12554922 @default.
• W2521178821 hasConcept C127313418 @default.
• W2521178821 hasConcept C139425391 @default.
• W2521178821 hasConcept C159467904 @default.
• W2521178821 hasConcept C171250308 @default.
• W2521178821 hasConcept C185592680 @default.
• W2521178821 hasConcept C186060115 @default.
• W2521178821 hasConcept C18762648 @default.
• W2521178821 hasConcept C192562407 @default.
• W2521178821 hasConcept C24890656 @default.
• W2521178821 hasConcept C2777289219 @default.
• W2521178821 hasConcept C41008148 @default.
• W2521178821 hasConcept C57879066 @default.
• W2521178821 hasConcept C62520636 @default.
• W2521178821 hasConcept C65655974 @default.
• W2521178821 hasConcept C74650414 @default.
• W2521178821 hasConcept C86803240 @default.
• W2521178821 hasConcept C89611455 @default.
• W2521178821 hasConcept C97355855 @default.
• W2521178821 hasConcept C98045186 @default.
• W2521178821 hasConceptScore W2521178821C104114177 @default.
• W2521178821 hasConceptScore W2521178821C111368507 @default.
• W2521178821 hasConceptScore W2521178821C111919701 @default.
• W2521178821 hasConceptScore W2521178821C121332964 @default.
• W2521178821 hasConceptScore W2521178821C12554922 @default.
• W2521178821 hasConceptScore W2521178821C127313418 @default.
• W2521178821 hasConceptScore W2521178821C139425391 @default.
• W2521178821 hasConceptScore W2521178821C159467904 @default.
• W2521178821 hasConceptScore W2521178821C171250308 @default.
• W2521178821 hasConceptScore W2521178821C185592680 @default.
• W2521178821 hasConceptScore W2521178821C186060115 @default.
• W2521178821 hasConceptScore W2521178821C18762648 @default.
• W2521178821 hasConceptScore W2521178821C192562407 @default.

• next