FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2521198002> ?p ?o ?g. }

• W2521198002 endingPage "11554" @default.
• W2521198002 startingPage "11549" @default.
• W2521198002 abstract "Most cases of oral squamous cell carcinoma (OSCC) develop from visible oral potentially malignant disorders (OPMDs). The latter exhibit heterogeneous subtypes with different transformation potentials, complicating the early detection of OSCC during routine visual oral cancer screenings. To develop clinically applicable biomarkers, we collected saliva samples from 96 healthy controls, 103 low-risk OPMDs, 130 high-risk OPMDs, and 131 OSCC subjects. These individuals were enrolled in Taiwan's Oral Cancer Screening Program. We identified 302 protein biomarkers reported in the literature and/or through in-house studies and prioritized 49 proteins for quantification in the saliva samples using multiple reaction monitoring-MS. Twenty-eight proteins were successfully quantified with high confidence. The quantification data from non-OSCC subjects (healthy controls + low-risk OPMDs) and OSCC subjects in the training set were subjected to classification and regression tree analyses, through which we generated a four-protein panel consisting of MMP1, KNG1, ANXA2, and HSPA5. A risk-score scheme was established, and the panel showed high sensitivity (87.5%) and specificity (80.5%) in the test set to distinguish OSCC samples from non-OSCC samples. The risk score >0.4 detected 84% (42/50) of the stage I OSCCs and a significant portion (42%) of the high-risk OPMDs. Moreover, among 88 high-risk OPMD patients with available follow-up results, 18 developed OSCC within 5 y; of them, 77.8% (14/18) had risk scores >0.4. Our four-protein panel may therefore offer a clinically effective tool for detecting OSCC and monitoring high-risk OPMDs through a readily available biofluid." @default.
• W2521198002 created "2016-09-30" @default.
• W2521198002 creator A5000614895 @default.
• W2521198002 creator A5004609046 @default.
• W2521198002 creator A5007244502 @default.
• W2521198002 creator A5007732230 @default.
• W2521198002 creator A5016879896 @default.
• W2521198002 creator A5019389546 @default.
• W2521198002 creator A5022647839 @default.
• W2521198002 creator A5023309672 @default.
• W2521198002 creator A5024278385 @default.
• W2521198002 creator A5024395460 @default.
• W2521198002 creator A5025361204 @default.
• W2521198002 creator A5029285453 @default.
• W2521198002 creator A5031354828 @default.
• W2521198002 creator A5039271498 @default.
• W2521198002 creator A5044059241 @default.
• W2521198002 creator A5045338514 @default.
• W2521198002 creator A5049735724 @default.
• W2521198002 creator A5055448005 @default.
• W2521198002 creator A5055833929 @default.
• W2521198002 creator A5061602962 @default.
• W2521198002 creator A5068955653 @default.
• W2521198002 creator A5072458957 @default.
• W2521198002 creator A5075505594 @default.
• W2521198002 creator A5077952101 @default.
• W2521198002 creator A5083881596 @default.
• W2521198002 date "2016-09-23" @default.
• W2521198002 modified "2023-10-10" @default.
• W2521198002 title "Saliva protein biomarkers to detect oral squamous cell carcinoma in a high-risk population in Taiwan" @default.
• W2521198002 cites W1630865570 @default.
• W2521198002 cites W1863578670 @default.
• W2521198002 cites W1967411316 @default.
• W2521198002 cites W1994715030 @default.
• W2521198002 cites W2016081624 @default.
• W2521198002 cites W2022071819 @default.
• W2521198002 cites W2056971386 @default.
• W2521198002 cites W2066648341 @default.
• W2521198002 cites W2069304635 @default.
• W2521198002 cites W2092856255 @default.
• W2521198002 cites W2101336111 @default.
• W2521198002 cites W2111627225 @default.
• W2521198002 cites W2121060043 @default.
• W2521198002 cites W2121674890 @default.
• W2521198002 cites W2123823520 @default.
• W2521198002 cites W2126925889 @default.
• W2521198002 cites W2128490578 @default.
• W2521198002 cites W2148818765 @default.
• W2521198002 cites W2157257183 @default.
• W2521198002 cites W2159015502 @default.
• W2521198002 cites W2162766713 @default.
• W2521198002 cites W2164678074 @default.
• W2521198002 cites W2170791918 @default.
• W2521198002 cites W2326362277 @default.
• W2521198002 doi "https://doi.org/10.1073/pnas.1612368113" @default.
• W2521198002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5068314" @default.
• W2521198002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27663741" @default.
• W2521198002 hasPublicationYear "2016" @default.
• W2521198002 type Work @default.
• W2521198002 sameAs 2521198002 @default.
• W2521198002 citedByCount "83" @default.
• W2521198002 countsByYear W25211980022016 @default.
• W2521198002 countsByYear W25211980022017 @default.
• W2521198002 countsByYear W25211980022018 @default.
• W2521198002 countsByYear W25211980022019 @default.
• W2521198002 countsByYear W25211980022020 @default.
• W2521198002 countsByYear W25211980022021 @default.
• W2521198002 countsByYear W25211980022022 @default.
• W2521198002 countsByYear W25211980022023 @default.
• W2521198002 crossrefType "journal-article" @default.
• W2521198002 hasAuthorship W2521198002A5000614895 @default.
• W2521198002 hasAuthorship W2521198002A5004609046 @default.
• W2521198002 hasAuthorship W2521198002A5007244502 @default.
• W2521198002 hasAuthorship W2521198002A5007732230 @default.
• W2521198002 hasAuthorship W2521198002A5016879896 @default.
• W2521198002 hasAuthorship W2521198002A5019389546 @default.
• W2521198002 hasAuthorship W2521198002A5022647839 @default.
• W2521198002 hasAuthorship W2521198002A5023309672 @default.
• W2521198002 hasAuthorship W2521198002A5024278385 @default.
• W2521198002 hasAuthorship W2521198002A5024395460 @default.
• W2521198002 hasAuthorship W2521198002A5025361204 @default.
• W2521198002 hasAuthorship W2521198002A5029285453 @default.
• W2521198002 hasAuthorship W2521198002A5031354828 @default.
• W2521198002 hasAuthorship W2521198002A5039271498 @default.
• W2521198002 hasAuthorship W2521198002A5044059241 @default.
• W2521198002 hasAuthorship W2521198002A5045338514 @default.
• W2521198002 hasAuthorship W2521198002A5049735724 @default.
• W2521198002 hasAuthorship W2521198002A5055448005 @default.
• W2521198002 hasAuthorship W2521198002A5055833929 @default.
• W2521198002 hasAuthorship W2521198002A5061602962 @default.
• W2521198002 hasAuthorship W2521198002A5068955653 @default.
• W2521198002 hasAuthorship W2521198002A5072458957 @default.
• W2521198002 hasAuthorship W2521198002A5075505594 @default.
• W2521198002 hasAuthorship W2521198002A5077952101 @default.
• W2521198002 hasAuthorship W2521198002A5083881596 @default.
• W2521198002 hasBestOaLocation W25211980021 @default.
• W2521198002 hasConcept C104317684 @default.
• W2521198002 hasConcept C121608353 @default.

• next