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• W2521258635 endingPage "e0163202" @default.
• W2521258635 startingPage "e0163202" @default.
• W2521258635 abstract "Background and Objective Alterations of brain morphology in Crohn’s disease have been reported, but data is scarce and heterogenous and the possible impact of disease predisposition on brain development is unknown. Assuming a systemic course of the disease, brain involvement seems more probable in presence of extraintestinal manifestations, but this question has not yet been addressed. The present study examined the relationship between Crohn’s disease and brain structure and focused on the connection with extraintestinal manifestations and markers of brain development. Methods In a pilot study, brains of 15 patients with Crohn’s disease (of which 9 had a history of extraintestinal manifestations, i.e. arthritis, erythema nodosum and primary sclerosing cholangitis) were compared to matched healthy controls using high resolution magnetic resonance imaging. Patients and controls were tested for depression, fatigue and global cognitive function. Cortical thickness, surface area and folding were determined via cortical surface modeling. Results The overall group comparison (i.e. all patients vs. controls) yielded no significant results. In the patient subgroup with extraintestinal manifestations, changes in cortical area and folding, but not thickness, were identified: Patients showed elevated cortical surface area in the left middle frontal lobe (p<0.05) and hypergyrification in the left lingual gyrus (p<0.001) compared to healthy controls. Hypogyrification of the right insular cortex (p<0.05) and hypergyrification of the right anterior cingulate cortex (p<0.001) were detected in the subgroup comparison of patients with against without extraintestinal manifestations. P-values are corrected for multiple comparisons. Conclusions Our findings lend further support to the hypothesis that Crohn’s disease is associated with aberrant brain structure and preliminary support for the hypothesis that these changes are associated with a systemic course of the disease as indicated by extraintestinal manifestations. Changes in cortical surface area and folding suggest a possible involvement of Crohn’s disease or its predisposition during brain development." @default.
• W2521258635 created "2016-09-30" @default.
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• W2521258635 date "2016-09-21" @default.
• W2521258635 modified "2023-10-18" @default.
• W2521258635 title "Altered Markers of Brain Development in Crohn’s Disease with Extraintestinal Manifestations – A Pilot Study" @default.
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• W2521258635 cites W1903220916 @default.
• W2521258635 cites W1970741301 @default.
• W2521258635 cites W1976899564 @default.
• W2521258635 cites W1977275002 @default.
• W2521258635 cites W1983355263 @default.
• W2521258635 cites W1985450019 @default.
• W2521258635 cites W1989262443 @default.
• W2521258635 cites W1996923810 @default.
• W2521258635 cites W1997774819 @default.
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• W2521258635 doi "https://doi.org/10.1371/journal.pone.0163202" @default.
• W2521258635 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5031401" @default.
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• W2521258635 hasPublicationYear "2016" @default.
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