Matches in SemOpenAlex for { <https://semopenalex.org/work/W2521567171> ?p ?o ?g. }
- W2521567171 endingPage "225" @default.
- W2521567171 startingPage "191" @default.
- W2521567171 abstract "Severe sepsis, septic shock, and related inflammatory syndromes are driven by the aberrant expression of proinflammatory mediators by immune cells. During the acute phase of sepsis, overexpression of chemokines and cytokines drives physiological stress leading to organ failure and mortality. Following recovery from sepsis, the immune system exhibits profound immunosuppression, evidenced by an inability to produce the same proinflammatory mediators that are required for normal responses to infectious microorganisms. Gene expression in inflammatory responses is influenced by the transcriptional accessibility of the chromatin, with histone posttranslational modifications determining whether inflammatory gene loci are set to transcriptionally active, repressed, or poised states. Experimental evidence indicates that histone modifications play a central role in governing the cytokine storm of severe sepsis, and that aberrant chromatin modifications induced during the acute phase of sepsis may mediate chronic immunosuppression in sepsis survivors. This review will focus on the role of histone modifications in governing immune responses in severe sepsis, with an emphasis on specific leukocyte subsets and the histone modifications observed in these cells during chronic stages of sepsis. Additionally, the expression and function of chromatin-modifying enzymes (CMEs) will be discussed in the context of severe sepsis, as potential mediators of epigenetic regulation of gene expression in sepsis responses. In summary, this review will argue for the use of chromatin modifications and CME expression in leukocytes as potential biomarkers of immunosuppression in patients with severe sepsis." @default.
- W2521567171 created "2016-09-30" @default.
- W2521567171 creator A5004928457 @default.
- W2521567171 creator A5033934471 @default.
- W2521567171 date "2017-01-01" @default.
- W2521567171 modified "2023-10-16" @default.
- W2521567171 title "Regulation of Cellular Immune Responses in Sepsis by Histone Modifications" @default.
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