FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2521669641> ?p ?o ?g. }

• W2521669641 endingPage "143" @default.
• W2521669641 startingPage "142" @default.
• W2521669641 abstract "PURPOSE: To introduce resting-state connectivity fMRI as a tool to investigate early neurofunctional impact of surgical intervention (cranial expansion) in infants with non-syndromic sagittal synostosis. METHODS: Six healthy infants with non-syndromic sagittal synostosis underwent preop fMRI scan without sedation (mean age 26 wks), followed by open cranial vault expansion (mean 30.5 wks), followed by post-op fMRI scan (mean 43 wks) with IRB approval. Resting connectivity was selected as it is a task-independent metric and can provide useful information with regard to generalized brain function in newborns. Sleeping subjects were placed supine in a 3.0T General Electric Signa LX scanner equipped with a 32 channel receiver head coil. A fast axial 3 dimensional Spoiled Gradient Echo (3D-SPGR) image was acquired for each single subject before functional imaging session, consisting of 150 slices acquired: slice thickness of 1mm, TR=8.2ms, TE=3.2ms, flip angle=12 degree, FOV=240mm, matrix=256X224. High resolution anatomical images were used for subsequent superimposition of the low–resolution functional MRI data. Functional EPI scans were acquired at a slice thickness of 2.5mm, total 31 slices, FOV 240mm, TR=2000 ms, TR=22 ms, flip angle=77 degree, matrix=96X96. Analysis of Functional Neuroimaging (AFNI) software was used to register and analyze imaging data, and identify neural networks demonstrating altered resting connectivity before and after surgery. RESULTS: Early data acquisition was plagued by motion artifact and physiologic perturbation confounding the results. The focus of this report compares clean pre- and post-operative datasets in the same individual; preliminary analysis confirms improved resting state connectivity in both the visual and sensorimotor networks, both in amplitude of BOLD signal and the extent of the networks. Furthermore, the networks in general in several subjects show improved symmetry following surgery. CONCLUSIONS: Resting-state connectivity fMRI is a sensitive and objective means of measuring functional impact on brain function of surgical treatment, and can be safely employed in infants. In cranial surgery the acute expansion of the intracranial space undoubtedly affects intracranial pressure dynamics, which impacts neuronal activity reflected in an altered BOLD signal. If preservation of brain function is the overarching goal of surgery, and not simply cosmesis, fMRI will provide the means to prove it, as well as have future application as an objective measure by which to validate more traditional neuropsychological testing in this population." @default.
• W2521669641 created "2016-09-30" @default.
• W2521669641 creator A5015931887 @default.
• W2521669641 creator A5033196165 @default.
• W2521669641 creator A5037552584 @default.
• W2521669641 creator A5051755473 @default.
• W2521669641 creator A5069773948 @default.
• W2521669641 creator A5077933398 @default.
• W2521669641 date "2016-09-01" @default.
• W2521669641 modified "2023-10-18" @default.
• W2521669641 title "Abstract" @default.
• W2521669641 doi "https://doi.org/10.1097/01.gox.0000503071.01169.f5" @default.
• W2521669641 hasPublicationYear "2016" @default.
• W2521669641 type Work @default.
• W2521669641 sameAs 2521669641 @default.
• W2521669641 citedByCount "0" @default.
• W2521669641 crossrefType "journal-article" @default.
• W2521669641 hasAuthorship W2521669641A5015931887 @default.
• W2521669641 hasAuthorship W2521669641A5033196165 @default.
• W2521669641 hasAuthorship W2521669641A5037552584 @default.
• W2521669641 hasAuthorship W2521669641A5051755473 @default.
• W2521669641 hasAuthorship W2521669641A5069773948 @default.
• W2521669641 hasAuthorship W2521669641A5077933398 @default.
• W2521669641 hasBestOaLocation W25216696411 @default.
• W2521669641 hasConcept C118552586 @default.
• W2521669641 hasConcept C125567185 @default.
• W2521669641 hasConcept C126838900 @default.
• W2521669641 hasConcept C141071460 @default.
• W2521669641 hasConcept C154945302 @default.
• W2521669641 hasConcept C178910020 @default.
• W2521669641 hasConcept C2779010991 @default.
• W2521669641 hasConcept C2989005 @default.
• W2521669641 hasConcept C41008148 @default.
• W2521669641 hasConcept C58693492 @default.
• W2521669641 hasConcept C66324658 @default.
• W2521669641 hasConcept C71924100 @default.
• W2521669641 hasConceptScore W2521669641C118552586 @default.
• W2521669641 hasConceptScore W2521669641C125567185 @default.
• W2521669641 hasConceptScore W2521669641C126838900 @default.
• W2521669641 hasConceptScore W2521669641C141071460 @default.
• W2521669641 hasConceptScore W2521669641C154945302 @default.
• W2521669641 hasConceptScore W2521669641C178910020 @default.
• W2521669641 hasConceptScore W2521669641C2779010991 @default.
• W2521669641 hasConceptScore W2521669641C2989005 @default.
• W2521669641 hasConceptScore W2521669641C41008148 @default.
• W2521669641 hasConceptScore W2521669641C58693492 @default.
• W2521669641 hasConceptScore W2521669641C66324658 @default.
• W2521669641 hasConceptScore W2521669641C71924100 @default.
• W2521669641 hasIssue "9S" @default.
• W2521669641 hasLocation W25216696411 @default.
• W2521669641 hasLocation W25216696412 @default.
• W2521669641 hasLocation W25216696413 @default.
• W2521669641 hasOpenAccess W2521669641 @default.
• W2521669641 hasPrimaryLocation W25216696411 @default.
• W2521669641 hasRelatedWork W1682399919 @default.
• W2521669641 hasRelatedWork W2019907648 @default.
• W2521669641 hasRelatedWork W2062469140 @default.
• W2521669641 hasRelatedWork W2106024703 @default.
• W2521669641 hasRelatedWork W2257950314 @default.
• W2521669641 hasRelatedWork W2589069782 @default.
• W2521669641 hasRelatedWork W2750804055 @default.
• W2521669641 hasRelatedWork W2977916355 @default.
• W2521669641 hasRelatedWork W3034470327 @default.
• W2521669641 hasRelatedWork W190208561 @default.
• W2521669641 hasVolume "4" @default.
• W2521669641 isParatext "false" @default.
• W2521669641 isRetracted "false" @default.
• W2521669641 magId "2521669641" @default.
• W2521669641 workType "article" @default.