Matches in SemOpenAlex for { <https://semopenalex.org/work/W2521716553> ?p ?o ?g. }
- W2521716553 endingPage "429" @default.
- W2521716553 startingPage "423" @default.
- W2521716553 abstract "A novel series of triazine-triazole derivatives 7a-7m were synthesized, characterized by 1H NMR and evaluated for their α-glucosidase inhibitory activity. All the synthesized compounds displayed potent α-glucosidase inhibitory activity with IC50 range of 11.63 ± 0.15 to 37.44 ± 0.35 μM, when compared to the standard drug acarbose (IC50 = 817.38 ± 6.27 μM). Among the series, compound 7i (IC50 = 11.63 ± 0.15 μM) bearing 2,5-dichloro substitution at phenyl ring, represented the most potent α-glucosidase inhibitory activity. Molecular docking studies of the most active compounds with the homology modelled α-glucosidase were also performed to explore the possible inhibitory mechanism. Our studies shown that these triazine-triazole derivatives are a new class of α-glucosidase inhibitors." @default.
- W2521716553 created "2016-09-30" @default.
- W2521716553 creator A5021001459 @default.
- W2521716553 creator A5022526821 @default.
- W2521716553 creator A5047925888 @default.
- W2521716553 creator A5064711465 @default.
- W2521716553 creator A5087318744 @default.
- W2521716553 date "2017-01-01" @default.
- W2521716553 modified "2023-10-06" @default.
- W2521716553 title "Synthesis, in vitro evaluation and molecular docking studies of novel triazine-triazole derivatives as potential α-glucosidase inhibitors" @default.
- W2521716553 cites W1517526224 @default.
- W2521716553 cites W1759879204 @default.
- W2521716553 cites W1963909139 @default.
- W2521716553 cites W1977851521 @default.
- W2521716553 cites W1978455823 @default.
- W2521716553 cites W1985658136 @default.
- W2521716553 cites W1987287280 @default.
- W2521716553 cites W1989664046 @default.
- W2521716553 cites W1990624278 @default.
- W2521716553 cites W2006522535 @default.
- W2521716553 cites W2029475615 @default.
- W2521716553 cites W2036254666 @default.
- W2521716553 cites W2037633981 @default.
- W2521716553 cites W2048565142 @default.
- W2521716553 cites W2051507935 @default.
- W2521716553 cites W2057013934 @default.
- W2521716553 cites W2059067578 @default.
- W2521716553 cites W2059272055 @default.
- W2521716553 cites W2061174398 @default.
- W2521716553 cites W2063855572 @default.
- W2521716553 cites W2074078250 @default.
- W2521716553 cites W2077605453 @default.
- W2521716553 cites W2077811490 @default.
- W2521716553 cites W2086589129 @default.
- W2521716553 cites W2089427958 @default.
- W2521716553 cites W2090135958 @default.
- W2521716553 cites W2090562487 @default.
- W2521716553 cites W2104625973 @default.
- W2521716553 cites W2122296176 @default.
- W2521716553 cites W2162586071 @default.
- W2521716553 cites W2165560933 @default.
- W2521716553 cites W2191975899 @default.
- W2521716553 cites W2338078927 @default.
- W2521716553 cites W2949895272 @default.
- W2521716553 cites W857389971 @default.
- W2521716553 doi "https://doi.org/10.1016/j.ejmech.2016.09.067" @default.
- W2521716553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27689725" @default.
- W2521716553 hasPublicationYear "2017" @default.
- W2521716553 type Work @default.
- W2521716553 sameAs 2521716553 @default.
- W2521716553 citedByCount "117" @default.
- W2521716553 countsByYear W25217165532017 @default.
- W2521716553 countsByYear W25217165532018 @default.
- W2521716553 countsByYear W25217165532019 @default.
- W2521716553 countsByYear W25217165532020 @default.
- W2521716553 countsByYear W25217165532021 @default.
- W2521716553 countsByYear W25217165532022 @default.
- W2521716553 countsByYear W25217165532023 @default.
- W2521716553 crossrefType "journal-article" @default.
- W2521716553 hasAuthorship W2521716553A5021001459 @default.
- W2521716553 hasAuthorship W2521716553A5022526821 @default.
- W2521716553 hasAuthorship W2521716553A5047925888 @default.
- W2521716553 hasAuthorship W2521716553A5064711465 @default.
- W2521716553 hasAuthorship W2521716553A5087318744 @default.
- W2521716553 hasConcept C159110408 @default.
- W2521716553 hasConcept C178790620 @default.
- W2521716553 hasConcept C178910836 @default.
- W2521716553 hasConcept C181199279 @default.
- W2521716553 hasConcept C185592680 @default.
- W2521716553 hasConcept C202751555 @default.
- W2521716553 hasConcept C21951064 @default.
- W2521716553 hasConcept C2776303721 @default.
- W2521716553 hasConcept C2776617576 @default.
- W2521716553 hasConcept C2777752497 @default.
- W2521716553 hasConcept C2777907353 @default.
- W2521716553 hasConcept C2780020378 @default.
- W2521716553 hasConcept C2781002465 @default.
- W2521716553 hasConcept C41183919 @default.
- W2521716553 hasConcept C41685203 @default.
- W2521716553 hasConcept C55493867 @default.
- W2521716553 hasConcept C71240020 @default.
- W2521716553 hasConcept C71924100 @default.
- W2521716553 hasConceptScore W2521716553C159110408 @default.
- W2521716553 hasConceptScore W2521716553C178790620 @default.
- W2521716553 hasConceptScore W2521716553C178910836 @default.
- W2521716553 hasConceptScore W2521716553C181199279 @default.
- W2521716553 hasConceptScore W2521716553C185592680 @default.
- W2521716553 hasConceptScore W2521716553C202751555 @default.
- W2521716553 hasConceptScore W2521716553C21951064 @default.
- W2521716553 hasConceptScore W2521716553C2776303721 @default.
- W2521716553 hasConceptScore W2521716553C2776617576 @default.
- W2521716553 hasConceptScore W2521716553C2777752497 @default.
- W2521716553 hasConceptScore W2521716553C2777907353 @default.
- W2521716553 hasConceptScore W2521716553C2780020378 @default.
- W2521716553 hasConceptScore W2521716553C2781002465 @default.
- W2521716553 hasConceptScore W2521716553C41183919 @default.
- W2521716553 hasConceptScore W2521716553C41685203 @default.
- W2521716553 hasConceptScore W2521716553C55493867 @default.