Matches in SemOpenAlex for { <https://semopenalex.org/work/W2521728131> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2521728131 abstract "Thecathepsin D (cath-D) gene, coding fora ubiquitous Iysosomal aspartyl protease, isoverexpressed in aggressive humanbreast cancers, anditstranscription is induced byestrogens inhormone-responsive breast cancer cells. We havedetermined thestructure andfunction ofthe proximal 5'upstream region ofthehumancath-D genefrom MCF7cells. We showthatthepromoter hasacompound structure withfeatures ofbothhousekeeping genes (high G+C content andpotential transcription factor Splsites) andreg- ulated genes (TATAAsequence). ByRNaseprotection assay, weshowthat transcription isinitiated atfive majortranscrip- tionsites (TSSI to-V)spanning 52basepairs. Inhormone- responsive breast cancer cells, estradiol increased by6-to 10-fold thelevel ofRNAsinitiated atTSSI, whichislocated about28basepairs downstream fromtheTATA box.The specific regulation byestradiol oftranscription starting atsite Iexclusively wasconfimed byprimer extension. Moreover, thesameestradiol effect wasobserved intheZR75-1 cell line andinMDA-Ml231estrogen-resistant breast cancer cells" @default.
- W2521728131 created "2016-09-30" @default.
- W2521728131 creator A5009780778 @default.
- W2521728131 date "1993-01-01" @default.
- W2521728131 modified "2023-09-23" @default.
- W2521728131 title "Cathepsin D geneiscontrolled byamixedpromoter, andestrogens stimulate onlyTATA-dependent transcription inbreast cancer cells" @default.
- W2521728131 hasPublicationYear "1993" @default.
- W2521728131 type Work @default.
- W2521728131 sameAs 2521728131 @default.
- W2521728131 citedByCount "0" @default.
- W2521728131 crossrefType "journal-article" @default.
- W2521728131 hasAuthorship W2521728131A5009780778 @default.
- W2521728131 hasConcept C104317684 @default.
- W2521728131 hasConcept C121608353 @default.
- W2521728131 hasConcept C138885662 @default.
- W2521728131 hasConcept C151701858 @default.
- W2521728131 hasConcept C153911025 @default.
- W2521728131 hasConcept C173633252 @default.
- W2521728131 hasConcept C179926584 @default.
- W2521728131 hasConcept C181199279 @default.
- W2521728131 hasConcept C41895202 @default.
- W2521728131 hasConcept C502942594 @default.
- W2521728131 hasConcept C530470458 @default.
- W2521728131 hasConcept C54355233 @default.
- W2521728131 hasConcept C55493867 @default.
- W2521728131 hasConcept C86339819 @default.
- W2521728131 hasConcept C86803240 @default.
- W2521728131 hasConcept C96232424 @default.
- W2521728131 hasConceptScore W2521728131C104317684 @default.
- W2521728131 hasConceptScore W2521728131C121608353 @default.
- W2521728131 hasConceptScore W2521728131C138885662 @default.
- W2521728131 hasConceptScore W2521728131C151701858 @default.
- W2521728131 hasConceptScore W2521728131C153911025 @default.
- W2521728131 hasConceptScore W2521728131C173633252 @default.
- W2521728131 hasConceptScore W2521728131C179926584 @default.
- W2521728131 hasConceptScore W2521728131C181199279 @default.
- W2521728131 hasConceptScore W2521728131C41895202 @default.
- W2521728131 hasConceptScore W2521728131C502942594 @default.
- W2521728131 hasConceptScore W2521728131C530470458 @default.
- W2521728131 hasConceptScore W2521728131C54355233 @default.
- W2521728131 hasConceptScore W2521728131C55493867 @default.
- W2521728131 hasConceptScore W2521728131C86339819 @default.
- W2521728131 hasConceptScore W2521728131C86803240 @default.
- W2521728131 hasConceptScore W2521728131C96232424 @default.
- W2521728131 hasLocation W25217281311 @default.
- W2521728131 hasOpenAccess W2521728131 @default.
- W2521728131 hasPrimaryLocation W25217281311 @default.
- W2521728131 hasRelatedWork W1503401968 @default.
- W2521728131 hasRelatedWork W1963997273 @default.
- W2521728131 hasRelatedWork W1970285094 @default.
- W2521728131 hasRelatedWork W1986829176 @default.
- W2521728131 hasRelatedWork W1999470996 @default.
- W2521728131 hasRelatedWork W2016194516 @default.
- W2521728131 hasRelatedWork W2020602336 @default.
- W2521728131 hasRelatedWork W2029364328 @default.
- W2521728131 hasRelatedWork W2035512375 @default.
- W2521728131 hasRelatedWork W2036243945 @default.
- W2521728131 hasRelatedWork W2044766101 @default.
- W2521728131 hasRelatedWork W2077987105 @default.
- W2521728131 hasRelatedWork W2079851469 @default.
- W2521728131 hasRelatedWork W2086263831 @default.
- W2521728131 hasRelatedWork W2144886407 @default.
- W2521728131 hasRelatedWork W2165825226 @default.
- W2521728131 hasRelatedWork W2167061296 @default.
- W2521728131 hasRelatedWork W2340617814 @default.
- W2521728131 hasRelatedWork W2810269450 @default.
- W2521728131 hasRelatedWork W2181593378 @default.
- W2521728131 isParatext "false" @default.
- W2521728131 isRetracted "false" @default.
- W2521728131 magId "2521728131" @default.
- W2521728131 workType "article" @default.