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- W2521761684 abstract "Abstract The intricate relationship between tuberculosis (TB) and immune system remains poorly understood. It is generally believed that weakening of the immune response against Mycobacterium tuberculosis leads to reactivation of latent infection into the active pulmonary disease. However, heterogeneous nature of TB and failure of rationally designed vaccines in clinical trials raises serious questions against the simplistic view of TB as an outcome of weakened immunity. In the wake of accumulating human TB data, it is argued here that a hyperactive antimycobacterial immune response is to blame for the pathogenesis of pulmonary TB in immunocompetent adults. Direct and indirect evidence supporting this notion is presented in this article. Revisiting the role of immune system in TB pathogenesis will pave the way for effective anti‐TB vaccines." @default.
- W2521761684 created "2016-09-30" @default.
- W2521761684 creator A5018449241 @default.
- W2521761684 date "2016-09-21" @default.
- W2521761684 modified "2023-09-27" @default.
- W2521761684 title "Adult pulmonary tuberculosis as a pathological manifestation of hyperactive antimycobacterial immune response" @default.
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- W2521761684 doi "https://doi.org/10.1186/s40169-016-0119-0" @default.
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