Matches in SemOpenAlex for { <https://semopenalex.org/work/W2521771323> ?p ?o ?g. }
- W2521771323 endingPage "e0162983" @default.
- W2521771323 startingPage "e0162983" @default.
- W2521771323 abstract "The Bifibobacterium longum subsp. longum 35624™ strain (formerly named Bifidobacterium longum subsp. infantis) is a well described probiotic with clinical efficacy in Irritable Bowel Syndrome clinical trials and induces immunoregulatory effects in mice and in humans. This paper presents (a) the genome sequence of the organism allowing the assignment to its correct subspeciation longum; (b) a comparative genome assessment with other B. longum strains and (c) the molecular structure of the 35624 exopolysaccharide (EPS624). Comparative genome analysis of the 35624 strain with other B. longum strains determined that the sub-speciation of the strain is longum and revealed the presence of a 35624-specific gene cluster, predicted to encode the biosynthetic machinery for EPS624. Following isolation and acid treatment of the EPS, its chemical structure was determined using gas and liquid chromatography for sugar constituent and linkage analysis, electrospray and matrix assisted laser desorption ionization mass spectrometry for sequencing and NMR. The EPS consists of a branched hexasaccharide repeating unit containing two galactose and two glucose moieties, galacturonic acid and the unusual sugar 6-deoxy-L-talose. These data demonstrate that the B. longum 35624 strain has specific genetic features, one of which leads to the generation of a characteristic exopolysaccharide." @default.
- W2521771323 created "2016-09-30" @default.
- W2521771323 creator A5009175302 @default.
- W2521771323 creator A5010604445 @default.
- W2521771323 creator A5011346688 @default.
- W2521771323 creator A5019871566 @default.
- W2521771323 creator A5032991843 @default.
- W2521771323 creator A5034770022 @default.
- W2521771323 creator A5037595742 @default.
- W2521771323 creator A5040086885 @default.
- W2521771323 creator A5042946289 @default.
- W2521771323 creator A5050116095 @default.
- W2521771323 creator A5050261718 @default.
- W2521771323 creator A5050264250 @default.
- W2521771323 creator A5051087379 @default.
- W2521771323 creator A5053694343 @default.
- W2521771323 creator A5053861514 @default.
- W2521771323 creator A5055404517 @default.
- W2521771323 creator A5070820916 @default.
- W2521771323 creator A5071374828 @default.
- W2521771323 creator A5077914575 @default.
- W2521771323 creator A5078201862 @default.
- W2521771323 creator A5081198610 @default.
- W2521771323 creator A5086339759 @default.
- W2521771323 date "2016-09-22" @default.
- W2521771323 modified "2023-10-18" @default.
- W2521771323 title "Genome Analysis and Characterisation of the Exopolysaccharide Produced by Bifidobacterium longum subsp. longum 35624™" @default.
- W2521771323 cites W1512811264 @default.
- W2521771323 cites W1560409804 @default.
- W2521771323 cites W1578890041 @default.
- W2521771323 cites W1858952731 @default.
- W2521771323 cites W1902150932 @default.
- W2521771323 cites W1922250837 @default.
- W2521771323 cites W1963588729 @default.
- W2521771323 cites W1965405546 @default.
- W2521771323 cites W1966110253 @default.
- W2521771323 cites W1976143575 @default.
- W2521771323 cites W1979487194 @default.
- W2521771323 cites W1980610596 @default.
- W2521771323 cites W1990585404 @default.
- W2521771323 cites W1998504591 @default.
- W2521771323 cites W2001894999 @default.
- W2521771323 cites W2003935644 @default.
- W2521771323 cites W2004785338 @default.
- W2521771323 cites W2008121639 @default.
- W2521771323 cites W2009145554 @default.
- W2521771323 cites W2011632697 @default.
- W2521771323 cites W2013200138 @default.
- W2521771323 cites W2013839711 @default.
- W2521771323 cites W2015509976 @default.
- W2521771323 cites W2015760801 @default.
- W2521771323 cites W2019522708 @default.
- W2521771323 cites W2039605189 @default.
- W2521771323 cites W2039622942 @default.
- W2521771323 cites W2043059762 @default.
- W2521771323 cites W2044971043 @default.
- W2521771323 cites W2045154619 @default.
- W2521771323 cites W2047133493 @default.
- W2521771323 cites W2048469790 @default.
- W2521771323 cites W2050116229 @default.
- W2521771323 cites W2054291714 @default.
- W2521771323 cites W2056812430 @default.
- W2521771323 cites W2056927024 @default.
- W2521771323 cites W2058858720 @default.
- W2521771323 cites W2065246237 @default.
- W2521771323 cites W2075210096 @default.
- W2521771323 cites W2079372195 @default.
- W2521771323 cites W2082137730 @default.
- W2521771323 cites W2084783008 @default.
- W2521771323 cites W2085979981 @default.
- W2521771323 cites W2088533607 @default.
- W2521771323 cites W2089653942 @default.
- W2521771323 cites W2090382915 @default.
- W2521771323 cites W2092871756 @default.
- W2521771323 cites W2104330483 @default.
- W2521771323 cites W2109232867 @default.
- W2521771323 cites W2109509831 @default.
- W2521771323 cites W2111211467 @default.
- W2521771323 cites W2114387498 @default.
- W2521771323 cites W2118523483 @default.
- W2521771323 cites W2119923823 @default.
- W2521771323 cites W2121016876 @default.
- W2521771323 cites W2127051694 @default.
- W2521771323 cites W2127757216 @default.
- W2521771323 cites W2128077684 @default.
- W2521771323 cites W2129690444 @default.
- W2521771323 cites W2132043383 @default.
- W2521771323 cites W2133790733 @default.
- W2521771323 cites W2137015675 @default.
- W2521771323 cites W2137061188 @default.
- W2521771323 cites W2140703378 @default.
- W2521771323 cites W2141885858 @default.
- W2521771323 cites W2142389241 @default.
- W2521771323 cites W2142830343 @default.
- W2521771323 cites W2165846721 @default.
- W2521771323 cites W2170488656 @default.
- W2521771323 cites W2185075416 @default.
- W2521771323 cites W2329508959 @default.