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• W2521845995 startingPage "1248" @default.
• W2521845995 abstract "Whole exome sequencing (WES) and whole genome sequencing (WGS) have become increasingly available in the research and clinical settings and are now also being offered by direct-to-consumer (DTC) genetic testing (GT) companies. This offer can be perceived as amplifying the already identified concerns regarding adequacy of informed consent (IC) for both WES/WGS and the DTC GT context. We performed a qualitative content analysis of Websites of four companies offering WES/WGS DTC regarding the following elements of IC: pre-test counseling, benefits and risks, and incidental findings (IFs). The analysis revealed concerns, including the potential lack of pre-test counseling in three of the companies studied, missing relevant information in the risks and benefits sections, and potentially misleading information for consumers. Regarding IFs, only one company, which provides opportunistic screening, provides basic information about their management. In conclusion, some of the information (and related practices) present on the companies’ Web pages salient to the consent process are not adequate in reference to recommendations for IC for WGS or WES in the clinical context. Requisite resources should be allocated to ensure that commercial companies are offering high-throughput sequencing under responsible conditions, including an adequate consent process." @default.
• W2521845995 created "2016-09-30" @default.
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• W2521845995 date "2016-10-05" @default.
• W2521845995 modified "2023-10-16" @default.
• W2521845995 title "Content Analysis of Informed Consent for Whole Genome Sequencing Offered by Direct-to-Consumer Genetic Testing Companies" @default.
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• W2521845995 doi "https://doi.org/10.1002/humu.23122" @default.
• W2521845995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27647801" @default.
• W2521845995 hasPublicationYear "2016" @default.
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