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- W2521854194 abstract "Purified decay-accelerating factor (DAF), from the stroma of normal human erythrocytes, was in- corporated into the membranes of erythrocytes of patients with paroxysmal nocturnal hemoglobinuria (PNH), and its effect on the compleiment sensitivity of the cells was investigated. Re- constitution with exogenous DAF restored the ability of the affected PNH cells to resist assembly of the homologous C3 convertase, C4b2a, on their surfaces, and decreased the susceptibility of the cells to lysis in acidified serum. Conversely, treatment of normal erythrocytes with monoclonal or polyclo- nal anti-DAF antibodies abrogated the capacity of the normal cells to 'circumvent C4b2a assembly and rendered the cells sensitive to acid lysis. These findings show that the previously reported association of DAF deficiency with PNH is causally related to the lytic abnormalities of the cells and clarify the molecular basis for restriction of autologous convertase forma- tion on normal human erythrocytes." @default.
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- W2521854194 date "2016-01-01" @default.
- W2521854194 modified "2023-09-28" @default.
- W2521854194 title "of paroxysmal nocturnal Lting factor" @default.
- W2521854194 hasPublicationYear "2016" @default.
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