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- W2521884992 abstract "The nuclear envelope is a unique topological structure formed by lipid membranes in eukaryotic cells. Unlike other membrane structures, the nuclear envelope comprises two concentric membrane shells fused at numerous sites with toroid-shaped pores that impart a geometric genus on the order of thousands. Despite the intriguing architecture and vital biological functions of the nuclear membranes, how they achieve and maintain such a unique arrangement remains unknown. Here, we used the theory of elasticity and differential geometry to analyze the equilibrium shape and stability of this structure. Our results show that modest in- and out-of-plane stresses present in the membranes not only can define the pore geometry, but also provide a mechanism for destabilizing membranes beyond a critical size and set the stage for the formation of new pores. Our results suggest a mechanism wherein nanoscale buckling instabilities can define the global topology of a nuclear envelope-like structure." @default.
- W2521884992 created "2016-09-30" @default.
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- W2521884992 date "2016-09-19" @default.
- W2521884992 modified "2023-10-16" @default.
- W2521884992 title "Ultradonut topology of the nuclear envelope" @default.
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- W2521884992 doi "https://doi.org/10.1073/pnas.1604777113" @default.
- W2521884992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5056109" @default.
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- W2521884992 hasPublicationYear "2016" @default.
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