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- W2521910223 abstract "The increasing prevalence of hyperglycaemia implicates a state of oxidative stress and inflammation. Traditional and emerging biomarkers associated with increasing hyperglycaemia were assessed to clarify their role they play in hyperglycaemia.309 participants attending a rural diabetic screening program were categorised into control and quintile groups based upon glucose levels: 1st quintile - <4.5 mmol/L and 4th, 5th quintile - >6.1 mmol/L. Significant results were obtained for anthropometric data and biochemical markers - glucose, HbA1c and total cholesterol (P < 0.001); oxidative stress: glutathione (P < 0.001), glutathione:glutathione disulfide and 8-hydroxy-2-deoxyguanosine (P < 0.05). Interleukin -1β and inflammatory marker ratios IL-6/IL-10, IL-1β/IL-10, MCP-1/IL-10, IGF-1/IL-10 and IL-6/IL-1β were significant (P < 0.05).This study provided further evidence that inflammatory and oxidative stress biomarkers may contribute to diagnostic information associated with preclinical increases in BGL. Further we have provided a unique study in the analysis of ratios of inflammatory biomarkers and correlations with increasing BGL." @default.
- W2521910223 created "2016-09-30" @default.
- W2521910223 creator A5011347476 @default.
- W2521910223 creator A5065965723 @default.
- W2521910223 date "2016-09-22" @default.
- W2521910223 modified "2023-10-13" @default.
- W2521910223 title "Hyperglycaemia, oxidative stress and inflammatory markers" @default.
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- W2521910223 doi "https://doi.org/10.1080/13510002.2016.1215643" @default.
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