Matches in SemOpenAlex for { <https://semopenalex.org/work/W2521913548> ?p ?o ?g. }
- W2521913548 endingPage "R165" @default.
- W2521913548 startingPage "R153" @default.
- W2521913548 abstract "Prolactin and prolactin receptor signaling and function are complex in nature and intricate in function. Basic, pre-clinical and translational research has opened up our eyes to the understanding that prolactin and prolactin receptor signaling function differently within different cellular contexts and microenvironmental conditions. Its multiple roles in normal physiology are subverted in cancer initiation and progression, and gradually we are teasing out the intricacies of function and therapeutic value. Recently, we observed that prolactin has a role in accelerating the time to bone metastasis in breast cancer patients and identified the mechanism by which prolactin stimulated breast cancer cell-mediated lytic osteoclast formation. The possibility that the prolactin receptor is a marker for metastasis, and specifically bone metastasis, is one that may have to be put into the context of the different variants of prolactin, different prolactin receptor isoforms and intricate signaling pathways that are regulated by the microenvironment. The more complete the picture, the better one can test biomarker identity and design clinical trials to test therapeutic intervention. This review will cover the recent advances and highlight the complexity of prolactin receptor biology." @default.
- W2521913548 created "2016-09-30" @default.
- W2521913548 creator A5013092722 @default.
- W2521913548 date "2016-11-01" @default.
- W2521913548 modified "2023-10-06" @default.
- W2521913548 title "Prolactin receptor in breast cancer: marker for metastatic risk" @default.
- W2521913548 cites W1488950205 @default.
- W2521913548 cites W1564078934 @default.
- W2521913548 cites W1868579164 @default.
- W2521913548 cites W1965659632 @default.
- W2521913548 cites W1968391872 @default.
- W2521913548 cites W1969460408 @default.
- W2521913548 cites W1972133083 @default.
- W2521913548 cites W1973396607 @default.
- W2521913548 cites W1976487404 @default.
- W2521913548 cites W1976764815 @default.
- W2521913548 cites W1977107368 @default.
- W2521913548 cites W1979050596 @default.
- W2521913548 cites W1979300653 @default.
- W2521913548 cites W1981887684 @default.
- W2521913548 cites W1984652911 @default.
- W2521913548 cites W1984848300 @default.
- W2521913548 cites W1990656224 @default.
- W2521913548 cites W1991352513 @default.
- W2521913548 cites W1992043148 @default.
- W2521913548 cites W1995733390 @default.
- W2521913548 cites W1996857936 @default.
- W2521913548 cites W1998002970 @default.
- W2521913548 cites W2000170468 @default.
- W2521913548 cites W2001501770 @default.
- W2521913548 cites W2004712158 @default.
- W2521913548 cites W2007627307 @default.
- W2521913548 cites W2010375751 @default.
- W2521913548 cites W2011501880 @default.
- W2521913548 cites W2025184730 @default.
- W2521913548 cites W2027721018 @default.
- W2521913548 cites W2034072513 @default.
- W2521913548 cites W2043568099 @default.
- W2521913548 cites W2044093336 @default.
- W2521913548 cites W2048460774 @default.
- W2521913548 cites W2048477123 @default.
- W2521913548 cites W2048915739 @default.
- W2521913548 cites W2053731769 @default.
- W2521913548 cites W2055918375 @default.
- W2521913548 cites W2058451029 @default.
- W2521913548 cites W2066122607 @default.
- W2521913548 cites W2070131418 @default.
- W2521913548 cites W2074126585 @default.
- W2521913548 cites W2074680809 @default.
- W2521913548 cites W2076930335 @default.
- W2521913548 cites W2078978161 @default.
- W2521913548 cites W2080072228 @default.
- W2521913548 cites W2086466867 @default.
- W2521913548 cites W2087239362 @default.
- W2521913548 cites W2087330517 @default.
- W2521913548 cites W2091462128 @default.
- W2521913548 cites W2093342179 @default.
- W2521913548 cites W2093838960 @default.
- W2521913548 cites W2093879092 @default.
- W2521913548 cites W2096579084 @default.
- W2521913548 cites W2097294190 @default.
- W2521913548 cites W2108184788 @default.
- W2521913548 cites W2110423968 @default.
- W2521913548 cites W2111825740 @default.
- W2521913548 cites W2112069875 @default.
- W2521913548 cites W2114128645 @default.
- W2521913548 cites W2115459009 @default.
- W2521913548 cites W2118284390 @default.
- W2521913548 cites W2122430082 @default.
- W2521913548 cites W2126464442 @default.
- W2521913548 cites W2126933826 @default.
- W2521913548 cites W2128426079 @default.
- W2521913548 cites W2128801071 @default.
- W2521913548 cites W2130447847 @default.
- W2521913548 cites W2132807638 @default.
- W2521913548 cites W2135702315 @default.
- W2521913548 cites W2136692995 @default.
- W2521913548 cites W2138287613 @default.
- W2521913548 cites W2139206204 @default.
- W2521913548 cites W2142739240 @default.
- W2521913548 cites W2143584784 @default.
- W2521913548 cites W2145299570 @default.
- W2521913548 cites W2146109980 @default.
- W2521913548 cites W2153013135 @default.
- W2521913548 cites W2156980924 @default.
- W2521913548 cites W2158497213 @default.
- W2521913548 cites W2162235294 @default.
- W2521913548 cites W2163485494 @default.
- W2521913548 cites W2164116473 @default.
- W2521913548 cites W2166834923 @default.
- W2521913548 cites W2169141341 @default.
- W2521913548 cites W2172618366 @default.
- W2521913548 cites W2293179109 @default.
- W2521913548 cites W2301343927 @default.
- W2521913548 cites W2325314951 @default.
- W2521913548 cites W2339339063 @default.
- W2521913548 cites W2339358819 @default.
- W2521913548 cites W2360712610 @default.