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- W2522295464 abstract "The nasal mucosa is considered to be the first defense line of the respiratory tract, protecting it from invading antigens. The local immunity of the nasal cavity has been well investigated and mucosal immunity has been proven to be present in nasal mucosa as well. We have been clarifying the mechanism of immune response in the nasal mucosa, employing mice as an experimental animal. Based on our quantitative analysis of the immunocompetent cell distribution in nasal mucosa, in the present study, the local immune response of murine nasal mucosa was examined when it was stimulated with repeated nasal challenges of protein antigen together with cholera toxin (CT), which is a potent mucosal adjuvant. In another study, the effect of viral infection in nasal cavity on the local and systemic immune response upon antigenic exposure to the nasal cavity was also examined.As results, cholera toxin provoked IgA antibody response with the mobilization of IgA-bearing B cells into the epithelial layer and submucosa of the nose. A morphological study showed follicle-like lymphocyte aggregates in the nasal submucosa and it is speculated that these lymphocyte aggregates serve as mucosa-associated lymphoid tissue such as Peyer's patches, because high endothelial venules are found in lymphocyte aggregates and M-cell like epithelial cells are seen among the ciliated epithelial lining. Type A influenza virus infection in the upper respiratory tract augmented systemic and local antibody (IgG/IgA) response to ovalbumin introduced into the nasal cavity.These results taken together suggest that nasal mucosa can be an afferent limb to provoke immune response of the nose and the effector site of systemic and mucosal immunity upon local antigenic exposures to the nose. Moreover, lymphocyte aggregates seen in nasal submucosa might be considered to be an inductive site of mucosal immunity, like Peyer's patch in the intestinal tract and it is possible that lymphocyte aggregates can be the source of antigen-driven B cells responding to the invading antigens to the nose. However, further direct studies designed from functional aspects are needed to have a definite answer." @default.
- W2522295464 created "2016-09-30" @default.
- W2522295464 date "1993-01-01" @default.
- W2522295464 modified "2023-09-26" @default.
- W2522295464 title "Local Immune Responce of the Murine Nasal Mucosa" @default.
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- W2522295464 doi "https://doi.org/10.7248/jjrhi1982.32.2_344" @default.
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