FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2522386126> ?p ?o ?g. }

• W2522386126 endingPage "e2371" @default.
• W2522386126 startingPage "e2371" @default.
• W2522386126 abstract "Abstract MicroRNAs, a class of small noncoding RNAs, have been implicated to regulate gene expression in virtually all important biological processes. Although accumulating evidence demonstrates that miR-150, an important regulator in hematopoiesis, is deregulated in various types of hematopoietic malignancies, the precise mechanisms of miR-150 action are largely unknown. In this study, we found that miR-150 is downregulated in samples from patients with acute lymphoblastic leukemia, acute myeloid leukemia, and chronic myeloid leukemia, and normalized after patients achieved complete remission. Restoration of miR-150 markedly inhibited growth and induced apoptosis of leukemia cells, and reduced tumorigenicity in a xenograft leukemia murine model. Microarray analysis identified multiple novel targets of miR-150, which were validated by quantitative real-time PCR and luciferase reporter assay. Gene ontology and pathway analysis illustrated potential roles of these targets in small-molecule metabolism, transcriptional regulation, RNA metabolism, proteoglycan synthesis in cancer, mTOR signaling pathway, or Wnt signaling pathway. Interestingly, knockdown one of four miR-150 targets ( EIF4B , FOXO4B , PRKCA , and TET3 ) showed an antileukemia activity similar to that of miR-150 restoration. Collectively, our study demonstrates that miR-150 functions as a tumor suppressor through multiple mechanisms in human leukemia and provides a rationale for utilizing miR-150 as a novel therapeutic agent for leukemia treatment." @default.
• W2522386126 created "2016-09-30" @default.
• W2522386126 creator A5006734524 @default.
• W2522386126 creator A5021810213 @default.
• W2522386126 creator A5023192145 @default.
• W2522386126 creator A5033207412 @default.
• W2522386126 creator A5041859247 @default.
• W2522386126 creator A5047508906 @default.
• W2522386126 creator A5056491380 @default.
• W2522386126 creator A5072941144 @default.
• W2522386126 creator A5075486072 @default.
• W2522386126 date "2016-09-22" @default.
• W2522386126 modified "2023-10-18" @default.
• W2522386126 title "miR-150 exerts antileukemia activity in vitro and in vivo through regulating genes in multiple pathways" @default.
• W2522386126 cites W1777054565 @default.
• W2522386126 cites W1815169428 @default.
• W2522386126 cites W1840244444 @default.
• W2522386126 cites W1972064898 @default.
• W2522386126 cites W1978402311 @default.
• W2522386126 cites W1991312668 @default.
• W2522386126 cites W1997062198 @default.
• W2522386126 cites W1999716161 @default.
• W2522386126 cites W2000750042 @default.
• W2522386126 cites W2018148000 @default.
• W2522386126 cites W2022728666 @default.
• W2522386126 cites W2024704386 @default.
• W2522386126 cites W2033371790 @default.
• W2522386126 cites W2038058004 @default.
• W2522386126 cites W2038067635 @default.
• W2522386126 cites W2044401303 @default.
• W2522386126 cites W2044453357 @default.
• W2522386126 cites W2047519730 @default.
• W2522386126 cites W2051888282 @default.
• W2522386126 cites W2062625397 @default.
• W2522386126 cites W2064941738 @default.
• W2522386126 cites W2065174573 @default.
• W2522386126 cites W2073872690 @default.
• W2522386126 cites W2079747084 @default.
• W2522386126 cites W2083381199 @default.
• W2522386126 cites W2084150442 @default.
• W2522386126 cites W2085442947 @default.
• W2522386126 cites W2092361147 @default.
• W2522386126 cites W2093904239 @default.
• W2522386126 cites W2104683328 @default.
• W2522386126 cites W2107501691 @default.
• W2522386126 cites W2115713281 @default.
• W2522386126 cites W2117263636 @default.
• W2522386126 cites W2117472344 @default.
• W2522386126 cites W2122958542 @default.
• W2522386126 cites W2133494347 @default.
• W2522386126 cites W2147983868 @default.
• W2522386126 cites W2158217645 @default.
• W2522386126 cites W2163199119 @default.
• W2522386126 cites W2170933474 @default.
• W2522386126 cites W2172000305 @default.
• W2522386126 cites W2217264961 @default.
• W2522386126 cites W2278657095 @default.
• W2522386126 cites W2425348388 @default.
• W2522386126 cites W1603432390 @default.
• W2522386126 doi "https://doi.org/10.1038/cddis.2016.256" @default.
• W2522386126 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5059860" @default.
• W2522386126 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27899822" @default.
• W2522386126 hasPublicationYear "2016" @default.
• W2522386126 type Work @default.
• W2522386126 sameAs 2522386126 @default.
• W2522386126 citedByCount "40" @default.
• W2522386126 countsByYear W25223861262017 @default.
• W2522386126 countsByYear W25223861262018 @default.
• W2522386126 countsByYear W25223861262019 @default.
• W2522386126 countsByYear W25223861262020 @default.
• W2522386126 countsByYear W25223861262021 @default.
• W2522386126 countsByYear W25223861262022 @default.
• W2522386126 countsByYear W25223861262023 @default.
• W2522386126 crossrefType "journal-article" @default.
• W2522386126 hasAuthorship W2522386126A5006734524 @default.
• W2522386126 hasAuthorship W2522386126A5021810213 @default.
• W2522386126 hasAuthorship W2522386126A5023192145 @default.
• W2522386126 hasAuthorship W2522386126A5033207412 @default.
• W2522386126 hasAuthorship W2522386126A5041859247 @default.
• W2522386126 hasAuthorship W2522386126A5047508906 @default.
• W2522386126 hasAuthorship W2522386126A5056491380 @default.
• W2522386126 hasAuthorship W2522386126A5072941144 @default.
• W2522386126 hasAuthorship W2522386126A5075486072 @default.
• W2522386126 hasBestOaLocation W25223861261 @default.
• W2522386126 hasConcept C104317684 @default.
• W2522386126 hasConcept C109159458 @default.
• W2522386126 hasConcept C137620995 @default.
• W2522386126 hasConcept C145059251 @default.
• W2522386126 hasConcept C150194340 @default.
• W2522386126 hasConcept C173396325 @default.
• W2522386126 hasConcept C203014093 @default.
• W2522386126 hasConcept C2778461978 @default.
• W2522386126 hasConcept C2778729363 @default.
• W2522386126 hasConcept C28328180 @default.
• W2522386126 hasConcept C502942594 @default.
• W2522386126 hasConcept C54355233 @default.
• W2522386126 hasConcept C62478195 @default.
• W2522386126 hasConcept C8415881 @default.

• next