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• W2522457189 endingPage "e0162904" @default.
• W2522457189 startingPage "e0162904" @default.
• W2522457189 abstract "Axial disorders are considered to appear late in the course of Parkinson's disease (PD). The associated impact on quality of life (QoL) and survival and the lack of an effective treatment mean that understanding and treating axial disorders is a key challenge. However, upper-body axial disorders (namely dysarthria, swallowing and breathing disorders) have never been prospectively assessed in early-stage PD patients.To characterize upper-body axial symptoms and QoL in consecutive patients with early-stage PD.We prospectively enrolled 66 consecutive patients with early-stage PD (less than 3 years of disease progression) and assessed dysarthria, dysphagia and respiratory function (relative to 36 controls) using both objective and patient-reported outcomes.The mean disease duration was 1.26 years and the mean UPDRS motor score was 19.4 out of 108. 74% of the patients presented slight dysarthria (primarily dysprosodia). Men appeared to be more severely affected (i.e. dysphonia). This dysfunction was strongly correlated with low swallowing speed (despite the absence of complaints about dysphagia), respiratory insufficiency and poor QoL. Videofluorography showed that oral-phase swallowing disorders affected 60% of the 31 tested patients and that pharyngeal-phase disorders affected 21%. 24% of the patients reported occasional dyspnea, which was correlated with anxiety in women but not in men. Marked diaphragmatic dysfunction was suspected in 42% of the patients (predominantly in men).Upper body axial symptoms were frequent in men with early-stage PD, whereas women presented worst non-motor impairments. New assessment methods are required because currently available tools do not reliably detect these upper-body axial disorders." @default.
• W2522457189 created "2016-09-30" @default.
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• W2522457189 date "2016-09-21" @default.
• W2522457189 modified "2023-10-06" @default.
• W2522457189 title "Are Upper-Body Axial Symptoms a Feature of Early Parkinson’s Disease?" @default.
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• W2522457189 doi "https://doi.org/10.1371/journal.pone.0162904" @default.
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