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- W2522531571 abstract "688 Background: The aim of our study was to highlight any time related changes in BC characteristics and surgical management of 3615 pts with early invasive tumours T1-T3 collected from 1992 to 2002 in Verona (Italy). Methods: We considered tumour size (T1, T2, T3), nodal involvement (N0, N1–3, N4–10, N>10), Grading (G1, G2, G3); Ki-67 (0–25%, 26–100%); ER, PgR, p21, p53, c-erbB2, BCL2 (-ve/+ve) and vascular invasion; age at diagnosis (< and > 50 years), modality of diagnosis (asymptomatic/symptomatic), type of surgery (conservative/radical), axillary dissection, number of examined nodes (N0–10, N>10) and reconstruction. Results: BC diagnosed more recently were smaller (T1: 54.9% in ’92 vs 74.9% in ’02; T2: 41.9% in ’92 vs 22.4% in ’02, p< 0.001) and among T1, T<10 mm were more frequent (19.5% in ’92 vs 32.8% in ’02; p<0.001); with lower nodal involvement (N0: 58.3% in ’92 vs 62.6% in ’02; p=0.02); higher Grading (G3: 24.4% in ’92 vs 28.9% in ’02; p=0.005); higher proliferation rate (Ki-67 > 25%: 11.9% in ’92 vs 14.5% in ’02; p<0.004); more frequently PgR+ve (34.4% in ’92 vs 68.9% in ’02; p<0.001); c-erbB2-ve (65.7% in ’94 vs 43.4% in ’02, p<0.001), p53-ve (66.7% in ’95 vs 86.2% in ’02; p<0.001) and with absence of vascular invasion (56% in ’97 vs 70.7% in ’02; p=0.04); no differences were seen in ER+ve, BCL2 and p21. Women with recently diagnosed early invasive BC were younger (< 50 years: 25.1% in ’92 vs 27.8% in ’02; p=0.01) and more frequently asymptomatic at diagnosis (22.1% in ’92 vs 52.5% in ’02; p<0.001). Conservative surgery increased (34% in ’92 to 77.4% in ’02; p<0.001); complete axillary dissection decreased (95.8% in ’92 vs 52.7% in ’02; p<0.001) with fewer examined nodes (N0–10: 20.5% in ’92 vs 25.6% in ’02; p<0.001) and reconstruction increased (40.2% in ’92 vs 90% in ’02; p<0.001). Conclusions: Some of our results seem to indicate that more recently diagnosed BC have better characteristics, possibly because of the introduction of screening in July ’99 (T1, N0, no vascular invasion); others indicate worse characteristics (higher Ki-67, more G3) possibly because of the younger age at diagnosis. Complete axillary dissection decreased since the introduction of sentinel node approach. No significant financial relationships to disclose." @default.
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- W2522531571 date "2005-06-01" @default.
- W2522531571 modified "2023-09-27" @default.
- W2522531571 title "How has early invasive breast cancer (BC) changed in the past decade? Analysis of 3615 consecutive patients (pts)" @default.
- W2522531571 doi "https://doi.org/10.1200/jco.2005.23.16_suppl.688" @default.
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