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• W2522544828 abstract "Functional polymorphisms in endogenous antioxidant defense genes including manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase (GPX-1) have been linked with risk of cancer at multiple sites. Although it is presumed that these germline variants impact disease risk by altering the host's ability to detoxify mutagenic reactive oxygen species, very few studies have directly examined this hypothesis. Concen- trations of 8-isoprostane F2a (8-iso-PGF2a) and 8-oxo-7, 8-dihydro-2 0 -deoxyguanosine (8-oxoxdG)—sensitive indi- cators of lipid peroxidation and DNA oxidation, respec- tively—were measured in 24-h urine samples obtained from 93 healthy, premenopausal women participating in a dietary intervention trial. In addition, DNA was extracted from blood for genotyping of MnSOD Val16Ala, CAT-262 C ( T, and GPX1 Pro198Leu genotypes by Taqman assay. Although geometric mean concentrations of 8-iso-PGF2a and 8-oxoxdG varied across several study characteristics including race, education level, body mass index, and serum antioxidant levels, there was little evidence that these biomarkers differed across any of the examined genotypes. In summary, functional polymorphisms in endogenous antioxidant defense genes do not appear to be strongly associated with systemic oxidative stress levels in young, healthy women." @default.
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• W2522544828 date "2011-01-01" @default.
• W2522544828 modified "2023-09-24" @default.
• W2522544828 title "Associations between functional polymorphisms in antioxidant defense genes and urinary oxidative stress biomarkers in healthy, premenopausal women Umaima Al-AlemPeter H. GannJeffrey Dahl • Richard B. van BreemenVilas MistryPatricia M. W. Lam • Mark D. EvansLinda Van HornMargaret E. Wright" @default.
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• W2522544828 hasPublicationYear "2011" @default.
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