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• W2522607424 abstract "Barrett's esophagus (BE) is defined as metaplasia of the esophageal squamous epithelium with multiple cell layers into a single layer of intestinal columnar epithelial cells - or, in other words, skyscrapers are turned into town houses. The underlying pathomechanism(s) and the cell of origin of BE lesions have not been defined yet. However, four potential hypotheses for BE development have been suggested. The morphological changes during BE development are associated with rather well-described aberrant gene/protein expression patterns. However, the potential key regulators of this conversion process are still unclear. The process of metaplastic conversion is difficult to monitor in a spatiotemporal manner in vitro, and robust models are lacking. There is therefore a need for novel experimental systems. This review focuses on potential key regulators, microenvironmental influences, epigenetic alterations and experimental research systems related to BE." @default.
• W2522607424 created "2016-09-30" @default.
• W2522607424 creator A5004453921 @default.
• W2522607424 creator A5007161363 @default.
• W2522607424 creator A5025593322 @default.
• W2522607424 creator A5062987908 @default.
• W2522607424 date "2016-09-23" @default.
• W2522607424 modified "2023-09-27" @default.
• W2522607424 title "Turning Skyscrapers into Town Houses: Insights into Barrett's Esophagus" @default.
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