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- W2522870862 abstract "The sphingosine 1-phosphate (S1P) receptors (S1PRs) are a group of G protein-coupled receptors expressed on the surface of lymphocytes. The interaction between S1P and S1PRs plays a significant role in the migration and distribution of lymphocytes.To investigate the influence of S1PR5 defect on the lymphocytes distribution in mice.The distribution of different subsets of lymphocyte in the mice with S1PR5 defect was examined by flow cytometry.Compared with wild type mice, the number of NK cells in the peripheral blood (PB) and spleen (SP) from the mice with S1PR5 defect decreased very significantly 〔PB: 6.4±0.45% vs 2.2±0.47(P<0.01,n=3)；SP: 3.0±0.91% vs 0.68±0.14%(P<0.05,n=3)〕. However, the NK cell number in the bone marrow (BM) and lymphonodes (LN) of the mice with S1PR5 defect increased very significantly 〔BM: 0.97±0.20 % vs 2.6±0.35% (P<0.01, n=3); LN: 0.35±0.16% vs 1.7±0.15% (P<0.01, n=3)〕. The percentages of CD3(+) lymphocyte in peripheral blood, spleen and lymph node were not statistically significantly different between these 2 types of mice 〔PB: 17.3±7.9% vs 17.0±4.6% (P>0.05, n=3); SP: 33.0±6.0% vs 27.4±1.8% (P>0.05, n=3); LN: 42.3±10.7% vs 51.2±2.7% (P>0.05, n=3)〕.S1PR5 defect can significantly influence the NK cell distribution." @default.
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- W2522870862 date "2016-08-01" @default.
- W2522870862 modified "2023-09-22" @default.
- W2522870862 title "[Influence of S1PR5 Defect on the Lymphocyte Distribution in Mice]." @default.
- W2522870862 doi "https://doi.org/10.7534/j.issn.1009-2137.2016.04.038" @default.
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