FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2522926417> ?p ?o ?g. }

• W2522926417 endingPage "6993" @default.
• W2522926417 startingPage "6983" @default.
• W2522926417 abstract "ABSTRACT Akkermansia muciniphila colonizes the mucus layer of the gastrointestinal tract, where the organism can be exposed to the oxygen that diffuses from epithelial cells. To understand how A. muciniphila is able to survive and grow at this oxic-anoxic interface, its oxygen tolerance and response and reduction capacities were studied. A. muciniphila was found to be oxygen tolerant. On top of this, under aerated conditions, A. muciniphila showed significant oxygen reduction capacities and its growth rate and yield were increased compared to those seen under strict anaerobic conditions. Transcriptome analysis revealed an initial oxygen stress response upon exposure to oxygen. Thereafter, genes related to respiration were expressed, including those coding for the cytochrome bd complex, which can function as a terminal oxidase. The functionality of A. muciniphila cytochrome bd genes was proven by successfully complementing cytochrome-deficient Escherichia coli strain ECOM4. We conclude that A. muciniphila can use oxygen when it is present at nanomolar concentrations. IMPORTANCE This article explains how Akkermansia muciniphila , previously described as a strictly anaerobic bacterium, is able to tolerate and even benefit from low levels of oxygen. Interestingly, we measured growth enhancement of A. muciniphila and changes in metabolism as a result of the oxygen exposure. In this article, we discuss similarities and differences of this oxygen-responsive mechanism with respect to those of other intestinal anaerobic isolates. Taken together, we think that these are valuable data that indicate how anaerobic intestinal colonizing bacteria can exploit low levels of oxygen present in the mucus layer and that our results have direct relevance for applicability, as addition of low oxygen concentrations could benefit the in vitro growth of certain anaerobic organisms." @default.
• W2522926417 created "2016-09-30" @default.
• W2522926417 creator A5023402491 @default.
• W2522926417 creator A5032471444 @default.
• W2522926417 creator A5041087137 @default.
• W2522926417 creator A5057409563 @default.
• W2522926417 creator A5063196220 @default.
• W2522926417 creator A5069967673 @default.
• W2522926417 creator A5087654889 @default.
• W2522926417 date "2016-12-01" @default.
• W2522926417 modified "2023-10-13" @default.
• W2522926417 title "Adaptation of Akkermansia muciniphila to the Oxic-Anoxic Interface of the Mucus Layer" @default.
• W2522926417 cites W1492422940 @default.
• W2522926417 cites W1537540248 @default.
• W2522926417 cites W1598752925 @default.
• W2522926417 cites W1810335376 @default.
• W2522926417 cites W1914622032 @default.
• W2522926417 cites W1964600830 @default.
• W2522926417 cites W1965552488 @default.
• W2522926417 cites W1988857358 @default.
• W2522926417 cites W1989959009 @default.
• W2522926417 cites W2005021548 @default.
• W2522926417 cites W2009706335 @default.
• W2522926417 cites W2012939480 @default.
• W2522926417 cites W2017113828 @default.
• W2522926417 cites W2020775251 @default.
• W2522926417 cites W2027352386 @default.
• W2522926417 cites W2029705820 @default.
• W2522926417 cites W2044438632 @default.
• W2522926417 cites W2049085828 @default.
• W2522926417 cites W2077248729 @default.
• W2522926417 cites W2077483511 @default.
• W2522926417 cites W2077980171 @default.
• W2522926417 cites W2094950455 @default.
• W2522926417 cites W2102619694 @default.
• W2522926417 cites W2107523606 @default.
• W2522926417 cites W2108234281 @default.
• W2522926417 cites W2114104545 @default.
• W2522926417 cites W2117595393 @default.
• W2522926417 cites W2131131384 @default.
• W2522926417 cites W2134241692 @default.
• W2522926417 cites W2136417551 @default.
• W2522926417 cites W2139334262 @default.
• W2522926417 cites W2147790901 @default.
• W2522926417 cites W2147893409 @default.
• W2522926417 cites W2153732314 @default.
• W2522926417 cites W2155924614 @default.
• W2522926417 cites W2170551349 @default.
• W2522926417 cites W2171424097 @default.
• W2522926417 cites W2183330967 @default.
• W2522926417 cites W2418807262 @default.
• W2522926417 cites W37545008 @default.
• W2522926417 cites W4242955410 @default.
• W2522926417 doi "https://doi.org/10.1128/aem.01641-16" @default.
• W2522926417 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5103097" @default.
• W2522926417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27663027" @default.
• W2522926417 hasPublicationYear "2016" @default.
• W2522926417 type Work @default.
• W2522926417 sameAs 2522926417 @default.
• W2522926417 citedByCount "92" @default.
• W2522926417 countsByYear W25229264172017 @default.
• W2522926417 countsByYear W25229264172018 @default.
• W2522926417 countsByYear W25229264172019 @default.
• W2522926417 countsByYear W25229264172020 @default.
• W2522926417 countsByYear W25229264172021 @default.
• W2522926417 countsByYear W25229264172022 @default.
• W2522926417 countsByYear W25229264172023 @default.
• W2522926417 crossrefType "journal-article" @default.
• W2522926417 hasAuthorship W2522926417A5023402491 @default.
• W2522926417 hasAuthorship W2522926417A5032471444 @default.
• W2522926417 hasAuthorship W2522926417A5041087137 @default.
• W2522926417 hasAuthorship W2522926417A5057409563 @default.
• W2522926417 hasAuthorship W2522926417A5063196220 @default.
• W2522926417 hasAuthorship W2522926417A5069967673 @default.
• W2522926417 hasAuthorship W2522926417A5087654889 @default.
• W2522926417 hasBestOaLocation W25229264171 @default.
• W2522926417 hasConcept C108970007 @default.
• W2522926417 hasConcept C178790620 @default.
• W2522926417 hasConcept C185592680 @default.
• W2522926417 hasConcept C18903297 @default.
• W2522926417 hasConcept C2775941767 @default.
• W2522926417 hasConcept C42407357 @default.
• W2522926417 hasConcept C48843007 @default.
• W2522926417 hasConcept C5140985 @default.
• W2522926417 hasConcept C523546767 @default.
• W2522926417 hasConcept C540031477 @default.
• W2522926417 hasConcept C54355233 @default.
• W2522926417 hasConcept C55493867 @default.
• W2522926417 hasConcept C86803240 @default.
• W2522926417 hasConcept C89423630 @default.
• W2522926417 hasConceptScore W2522926417C108970007 @default.
• W2522926417 hasConceptScore W2522926417C178790620 @default.
• W2522926417 hasConceptScore W2522926417C185592680 @default.
• W2522926417 hasConceptScore W2522926417C18903297 @default.
• W2522926417 hasConceptScore W2522926417C2775941767 @default.
• W2522926417 hasConceptScore W2522926417C42407357 @default.
• W2522926417 hasConceptScore W2522926417C48843007 @default.
• W2522926417 hasConceptScore W2522926417C5140985 @default.

• next