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- W2523002027 abstract "In the present study we observed that peritoneal and alveolar macrophages of mice produced non-plasminic fibrinolytic enzyme (NPFE) which was different from plasminogen activator (PA), and the activity of NPFE was enhanced when the macrophages were stimulated. The stimulation of macrophages was carried out by injecting heat killed Corynebacterium anaerobium into the abdominal cavity of mice, and the peritoneal and alveolar macrophages were harvested one week after, and then they were subjedted to cultivation in the medium (RPMI-1640) containing 20% fetal calf serum for up to 96 hours. The fibrinolytic activity in macrophages were observed by the fibrinolysis autograph according to Todd and the released fibrinolytic activity in the medium was analysed by the polyacrylamide gel electrophoresis and the fibrin plate method.The following results were obtained;1) The stimulated macrophages clearly demonstrated two types of fibrinolytic enzyme, one of which was NPFE, and the other was PA. The former lysed plasminogen-free fibrin, and its activity was inhibited with a specific non-plasminic fibrinolytic inhibitor, Boc-Try-Leu-Val-CH2Cl (TLVCK). The later lysed plasminogen-rich fibrin and its activity were inhibited with t-AMCHA.2) The NPFE in cells became undetectable when cells were kept in culture medium, whereas PA was still present during cultivation.3) The non-plasminic fibrinolytic enzyme activity was detected in the culture medium at the early cultivation phase, but tended to be undetectable at the late phase. On the other hand, the release of PA into the medium was ebserved to be retarded.4) Both NPFE and PA in the macrophages were determind to be basic proteins, but they were an electrophoretically different entity." @default.
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- W2523002027 date "1983-01-01" @default.
- W2523002027 modified "2023-10-16" @default.
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- W2523002027 doi "https://doi.org/10.2491/jjsth1970.14.370" @default.
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