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• W2523006872 abstract "To study ultrasonic characteristics of umbilical cord blood flow in acute fetal distress and its correlation with umbilical artery blood gas parameters, oxidative stress parameters, neonatal brain injury and myocardial injury. The pregnant women delivered in Department of Obstetrics of our hospital were chosen during the period from May 2012 to August 2015. The pregnant women with acute fetal distress were included in the distress group, and the healthy pregnant women with no acute fetal distress were included in the control group. The resistance index (RI), pulsatility index (PI) and systolic/diastolic (S/D) ratio of umbilical artery were measured at 24–30 weeks, 31–36 weeks and 37–41 weeks of pregnancy. After delivery, umbilical artery blood was taken for analysis of blood gas and determination of oxidative stress parameters. The venous blood of newborns was taken to measure the myocardial injury and brain injury parameters. At 24–30 weeks, 31–36 weeks and 37–41 weeks of pregnancy, RI, S/D and PI in pregnant women of distress group were significantly higher than those in control group. The pH, contents of arterial partial pressure of oxygen, vitamin C, vitamin E, superoxide dismutase and glutathione peroxidase in umbilical artery blood in pregnant women of distress group was significantly lower than those in control group and negatively correlated with the umbilical artery RI, PI and S/D. The contents of partial pressure of carbon dioxide in artery, lactic acid and malondialdehyde in pregnant women of distress group were significantly higher than those in control group and positively correlated with the umbilical artery RI, PI and S/D. The contents of lactate dehydrogenase, hydroxybutyrate dehydrogenase, creatine kinase, creatine kinase-MB, S100B, neuron-specific enolase, creatine kinase-BB and Tau in newborns' venous blood in distress group were significantly higher than those in control group and positively correlated with the umbilical artery RI, PI and S/D. The ultrasonic characteristics of umbilical cord blood flow in patients with acute fetal distress are increase of the resistance, reduction of blood flow, and significant reduction of ultrasonic parameters of RI, PI and S/D. The degree of hypoxia, oxidative stress, myocardial injury and brain injury can also be evaluated." @default.
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• W2523006872 date "2016-11-01" @default.
• W2523006872 modified "2023-09-24" @default.
• W2523006872 title "Ultrasonic characteristics and clinical significance of umbilical cord blood flow in acute fetal distress" @default.
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• W2523006872 doi "https://doi.org/10.1016/j.joad.2016.07.003" @default.
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