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- W2523015162 endingPage "1172" @default.
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- W2523015162 abstract "Gene organization and control are described by models conceived in the 1960s. These models explain basic gene regulatory mechanisms and underpin current genome annotation. However, such models struggle to explain recent genome-scale observations. For example, accounts of RNA synthesis initiating within genes, widespread antisense transcription and non-canonical DNA binding by gene regulatory proteins are difficult to reconcile with traditional thinking. As a result, unexpected observations have often been dismissed and downstream consequences ignored. In this paper I will argue that, to fully understand the biology of bacterial chromosomes, we must embrace their hidden layers of complexity." @default.
- W2523015162 created "2016-09-30" @default.
- W2523015162 creator A5024796305 @default.
- W2523015162 date "2016-07-01" @default.
- W2523015162 modified "2023-09-27" @default.
- W2523015162 title "The unexpected complexity of bacterial genomes" @default.
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- W2523015162 doi "https://doi.org/10.1099/mic.0.000309" @default.
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